922161-75-9

Upstream product

• 922163-01-7 3-(5-chloro-2-[(2,2-dimethylpropyl)amino]-3-[(S)-hydroxy-(2-methoxyphenyl)methyl]phenoxy)-2,2-dimethylpropan-1-ol 
• 1490-25-1 succinic acid monomethylester chloride 
• 922163-00-6 3-(5-chloro-2-[(2,2-dimethylpropyl)amino]-3-[hydroxy-(2-methoxyphenyl)methyl]phenoxy)-2,2-dimethylpropan-1-ol 
• 922162-99-0 N-(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[hydroxy(2-methoxyphenyl)methyl]phenyl)-2,2-dimethylpropanamide 
• 922162-98-9 N-[4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-phenyl]-2,2-dimethylpropanamide 
• 922162-97-8 N-[2-(3-([tert-butyl(dimethyl)silyl]oxy)-2,2-dimethylpropoxy)-4-chlorophenyl]-2,2-dimethylpropanamide 
• 922162-96-7 2-(3-([tert-butyl(dimethyl)silyl]oxy)-2,2-dimethylpropoxy)-4-chloroaniline 
• 922162-95-6 tert-butyl[3-(5-chloro-2-nitrophenoxy)-2,2-dimethylpropoxy]dimethylsilane 
• 117932-70-4 3-(tert-butyldimethylsilanyloxy)-2,2-dimethylpropan-1-ol 
• 135-02-4 ortho-anisaldehyde 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 

Downstream Products

• 922161-76-0 4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid 
• 922161-77-1 ethyl (3S)-1-(4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate 
• 922161-78-2 (3S)-1-(4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)-(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylicacid 

Relevant academic research and scientific papers

Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: Novel, highly potent and orally efficacious squalene synthase inhibitors

We have recently reported the discovery of the new benzhydrol template, which has a highly potent inhibitory activity for squalene synthase, as typified by compound 1 (SSI IC50 = 0.85 nM). However, it was composed of a pair of easy rotatable at