922166-23-2Relevant academic research and scientific papers
Enantioselective synthesis of nicotinic receptor probe 7,8-difluoro-1,2,3, 4,5,6-hexahydro-1,5-methano-3-benzazocine
Bashore, Crystal G.,Vetelino, Michael G.,Wirtz, Michael C.,Brooks, Paige R.,Frost, Heather N.,McDermott, Ruth E.,Whritenour, David C.,Ragan, John A.,Rutherford, Jennifer L.,Makowski, Teresa W.,Brenek, Steven J.,Coe, Jotham W.
, p. 5947 - 5950 (2007/10/03)
(Chemical Equation Presented) The development of a concise enantioselective synthesis of nicotinic alkaloid 1 is presented. The route features the synthesis and use of a "stable" aliphatic triflate 21 in an alkylation step to generate Heck precursor 24 and an enantioselective cyclization to establish a compound with the key [3.2.1]-bicyclic core, 29.
