922527-86-4Relevant academic research and scientific papers
Effect of crown ether ring size on binding and fluorescence response to saxitoxin in anthracylmethyl monoazacrown ether chemosensors
Mao, Hua,Thorne, John B.,Pharr, Jennifer S.,Gawley, Robert E.
, p. 1273 - 1279 (2006)
Convenient macrocyclization synthetic routes for the preparation of different-sized monoaza anthracylmethyl crown ether chemosensors (15-crown-5, 18-crown-6, 21-crown-7, 24-crown-8, and 27-crown-9) are described. Evaluation of these crowns as chemosensors for saxitoxin revealed that the larger crowns have moderately higher binding constants, with the 27-crown-9 chemosensor having the largest binding constant (2.29 × 105 (mol/L)-1). Fluorescence enhancements of 100% were observed at saxitoxin concentrations of 5 μmol/L, which is close to the detection limit in mouse bioassay.
