92254-66-5Relevant articles and documents
Three-Component Reaction of Dimethyl Malonate with α,β-Acetylenic Aldehydes and Amines. Synthesis of Push–Pull Buta-1,3-dienes
Sokov,Odin,Zlotskii,Golovanov
, p. 1758 - 1763 (2020)
Abstract: Three-component reaction of dimethyl malonate with α,β-acetylenic aldehydes and cyclic secondary amines (pyrrolidine, piperidine, morpholine, and piperazine) under mild conditions afforded dimethyl 2-(3-aminoprop-2-en-1-ylidene)malonates in 50–9
Phosphine-Mediated Dimerization of Conjugated Ene-Yne Ketones: Stereoselective Construction of Dihydrobenzofurans
Zhu, Cheng-Zhi,Sun, Yao-Liang,Wei, Yin,Shi, Min
, p. 1263 - 1270 (2017/04/18)
A new strategy for the phosphine-mediated dimerization of conjugated ene-yne ketones to produce functionalized dihydrobenzofurans has been developed, affording diversified 4,5-dihydrobenzofurans in moderate to excellent yields with high diastereoselectivities under mild conditions. This new synthetic method can tolerate a variety of functional groups and can be performed on a gram scale and in an asymmetric variant using the chiral phosphine Xyl-BINAP to give the desired products with up to 94% ee. (Figure presented.).
Organocatalytic asymmetric anti-selective Michael reactions of aldehydes and the sequential reduction/lactonization/pauson-khand reaction for the enantioselective synthesis of highly functionalized hydropentalenes
Hong, Bor-Cherng,Dange, Nitin S.,Yen, Po-Jen,Liao, Ju-Hsiou,Lee, Gene-Hsiang
supporting information, p. 5346 - 5349,4 (2020/09/02)
A new method has been developed for the enantioselective synthesis of highly functionalized hydropentalenes bearing up to four stereogenic centers with high stereoselectivity (up to 99% ee). This process combines an enantioselective organocatalytic anti-selective Michael addition with a highly efficient one-pot reduction/lactonization/Pauson-Khand reaction sequence. The structures and absolute configurations of the products were confirmed by X-ray analysis.
