92290-91-0 Usage
Sulfonamide derivative
A class of chemical compounds 2-([(4-CHLOROPHENYL)SULFONYL]ANILINO)ACETIC ACID belongs to the sulfonamide class, which is a group of compounds containing the sulfonamide functional group (-SO2NH2).
Analgesic and anti-inflammatory drug
Medicinal properties 2-([(4-CHLOROPHENYL)SULFONYL]ANILINO)ACETIC ACID is used to relieve pain (analgesic) and reduce inflammation (anti-inflammatory) in the body.
Nonsteroidal anti-inflammatory drugs (NSAIDs)
A class of drugs 2-([(4-CHLOROPHENYL)SULFONYL]ANILINO)ACETIC ACID is part of the NSAIDs, a group of drugs that provide anti-inflammatory and analgesic effects without the use of steroids.
Inhibition of prostaglandin production
Mechanism of action The compound works by inhibiting the production of prostaglandins, which are chemicals responsible for causing pain and inflammation in the body.
Oral administration
Route of administration The compound is typically taken orally in the form of tablets or capsules.
Side effects
Gastrointestinal disturbances, renal toxicity, and allergic reactions The use of 2-([(4-CHLOROPHENYL)SULFONYL]ANILINO)ACETIC ACID can be associated with various side effects, such as stomach issues, kidney damage, and allergic reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 92290-91-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,2,9 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 92290-91:
(7*9)+(6*2)+(5*2)+(4*9)+(3*0)+(2*9)+(1*1)=140
140 % 10 = 0
So 92290-91-0 is a valid CAS Registry Number.
92290-91-0Relevant academic research and scientific papers
N- and 2-Substituted N-(Phenylsulfonyl)glycines as Inhibitors of Rat Lens Aldose Reductase
DeRuiter, Jack,Borne, Ronald F.,Mayfield, Charles A.
, p. 145 - 151 (2007/10/02)
A variety of N-(phenylsulfonyl)-N-phenylglycines 5, N-(phenylsulfonyl)-2-phenylglycines 6, and N-(phenylsulfonyl)anthranilic acids 7 were prepared as analogues of the N-(phenylsulfonyl)glycine 1 aldose reductase inhibitors.In the rat lens assay, several derivatives of 5 display greater inhibitory activity than the corresponding glycines 1, suggesting that N-phenyl substitution enhances affinity for aldose reductase.Enzyme kinetic evaluations of the 4-benzoylamino analogues of 5 and 1 demonstrate that these compounds produce inhibition by the same mechanism.However, the significant differences in relative inhibitory potencies between compounds of series 5 and 1 may indicate that these compounds do not interact with the inhibitor binding site in precisely the same manner.Evaluation of the individual enantiomers of series 6 reveals that the S isomers are substantially more active than the corresponding R isomers.Also, with the exception of the naphthalene analogue 6n, the S stereoisomers of this series display greater inhibitory potencies than the glycines 1.The anthranilates 7 generally are less active than the glycines 1, demonstrating that direct incorporation of an aromatic ring in the glycine side chain may result in a decrease in affinity for aldose reductase.
