92292-01-8

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 62-53-3 aniline 
• 502-42-1 cycloheptanone 

Downstream Products

• 92373-78-9 1-anilino-cycloheptanecarboxylic acid amide 
• 1241960-48-4 spiro[cycloheptanyl-1',2-(5-imino-1-phenyl)pyrrolo(3,4-c)pyrazol(1H,2H)-5-one] 
• 1241960-63-3 spiro[cycloheptanyl-1',2-(3-amino-1-phenyl)pyrazinolidin-6-one] 
• 1241960-51-9 spiro[cycloheptanyl-1',2-(4-acetyl-3-amino-1-phenyl)pyrrol-5-one] 
• 1241960-54-2 spiro[cycloheptanyl-1',3-(2-imino-7-methyl-4-phenyl)-1,4-oxazepin-5-one] 
• 1241960-60-0 spiro[cycloheptanyl-1',4-(2,3-diphenyl-5-imino)-1,3-oxazolidine] 
• 1241960-69-9 spiro[cycloheptanyl-1',5-(2-amino-6-imino-4-phenyl)-1,3,4-thiadiazine] 
• 1241960-66-6 spiro[cycloheptanyl-1',3-(2-amino)thiazinolidin-5-one] 
• 1241960-45-1 spiro[cycloheptanyl-1',2-(3-amino-4-cyano-1-phenyl)pyrrol-5-one] 
• 1241960-74-6 spiro[cycloheptanyl-1',3-(4,6-diphenyl-2-imino)-1,4-oxazine] 
• 1241960-42-8 spiro[cycloheptanyl-1',2-(3-amino-4-cyano-5-imino-1-phenyl)pyrrole] 
• 1241960-57-5 spiro[cycloheptanyl-1',2-(3-amino-4-carbomethoxy-1-phenyl)pyrrol-5-one] 
• 1241960-79-1 spiro[cycloheptanyl-1',3-(2-imino-4-phenyl)-5,6-dihydro-1,4-oxazine] 
• 92321-63-6 1-anilinocycloheptanemethanol 

Relevant academic research and scientific papers

A microporous metal-organic framework catalyst for solvent-free strecker reaction and CO2 fixation at ambient conditions

The self-assembly of zinc(II) acetate tetrahydrate, a flexible tetrapyridyl ligand, tetrakis(3-pyridyloxymethylene)methane (3-tpom), a bent dicarboxylic acid, and 4,4′-(dimethylsilanediyl)bis- benzoic acid (H2L) under solvothermal conditions ha

Magnetic Fe3O4-BF3: Highly efficient Lewis acid catalyst for the synthesis of α-aminonitriles

Fe3O4 magnetic nanoparticle-supported BF3 was prepared as a new magnetically separable Lewis acid catalyst and successfully used for the one-pot synthesis of α-aminonitriles. A broad range of substrates including the aromatic and heteroaromatic aldehydes, cyclic ketones (cyclopentanone, cyclohexanone and cycloheptanone), aryl-alkyl ketones, diaryl ketones and tetralones, isatin derivatives and acenaphthenequinone were condensed with amines (aliphatic and aromatic) and trimethylsilyl cyanide. All reactions were completed in short times and products were obtained in good to excellent yields. The catalyst could be recycled and reused several times without any loss of efficiency. Finally, α-aminonitrile containing adenine was successfully synthesized.

A novel approach for the synthesis of α-aminonitriles using Mitsunobu's reagent under solvent-free conditions

A highly efficient, one-pot, three-component, solvent-free protocol for the synthesis of α-aminonitriles starting from their corresponding carbonyl compounds, amines, using Mitsunobu's reagent has been developed. Diversity of α-aminonitriles has been synthesized in good to excellent yields (80-99%) using various kinds of aldehydes/ketones and a variety of amines.

Zr(HSO4)4 catalyzed one-pot strecker synthesis of α-amino nitriles from aldehydes and ketones under solvent-free conditions

A mild and efficient method has been developed for the preparation of α-amino nitriles from the condensation of aldehydes and ketones with aniline and TMSCN in the presence of a catalytic amount of Zr(HSO 4)4 under solvent-free conditions at room temperature.

High pressure mediated three component Strecker synthesis of α-aminonitriles from ketones, aromatic amines and trimethylsilyl cyanide

High pressure (600 MPa) reaction conditions, in the absence of a catalyst, have proved to be a powerful way to stimulate the three component Strecker reaction synthesis of α-aminonitriles in high yields. Examples of two types of double Strecker reactions were also described.