923020-93-3Relevant academic research and scientific papers
Quinoline multi-target kinase inhibitor with antitumor activity and preparation method thereof
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Paragraph 0191; 0192, (2016/10/08)
The invention relates to a quinoline multi-target kinase inhibitor with antitumor activity and a preparation method thereof. A general structural formula of the compound is shown in a formula (I) described in the specification. In vitro cell experiments verify that the compound provided by the invention has strong in vitro inhibitory activity on five common tumor cell lines, namely human thyroid carcinoma SW579, human hepatic carcinoma HepG2, human lung adenocarcinoma A549, human colorectal adenocarcinoma HCT116 and human gastric carcinoma MKN45, antitumor activities of most of target compounds are better than or equivalent to that of a positive control drug Cabozantinib, and the in vitro cell experiments verify that the compound provided by the invention has strong inhibitory activity on two kinases KDR and MET, so that the compound provided by the invention has a broad application prospect in preparation of a new antitumor drug.
Synthesis of novel sterically demanding carbo- and heterocyclic β-ketoesters
Mihovilovic, Marko D.,Fischer, Thomas C. M.,Stanetty, Peter
, p. 357 - 364 (2007/10/03)
We present an easy method for the synthesis of β-ketoesters starting from various carbocyclic and heterocyclic carboxylic acids and esters. The β-ketoester side-chain was introduced by a sequence involving α-deprotonation and quenching with CO2
