923022-55-3

Upstream product

• 923022-53-1 7-chloro-6-fluoro-2H-isoquinolin-1-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 1202462-41-6 cis-1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-methyl-cyclohexyl]-propylamine 
• 1202462-33-6 1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine 
• 1202462-34-7 1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine 
• 1202007-15-5 cis-1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-cyclopropylamine 
• 1202007-19-9 cis-1-(4-{[1-(benzyloxy)-7-chloroisoquinolin-6-yl]oxy}-phenylcyclohexyl)-propanamine 
• 1202008-80-7 1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-cyclohexyl]-1-phenyl-ethylamine 
• 1202009-11-7 C-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-cyclohexyl]-C-(4-methoxy-phenyl)-methylamine 
• 1202009-10-6 C-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-cyclohexyl]-C-(4-methoxy-phenyl)-methylamine 
• 1202007-18-8 cis-6-{[4-(1-aminopropyl)-4-phenylcyclohexyl]oxy}-7-chloro-2H-isoquinolin-1-one 
• 1202009-25-3 cis-6-[4-((R)-1-amino-propyl)-4-phenyl-cyclohexyloxy]-7-chloro-2H-isoquinolin-1-one 
• 1202009-24-2 cis-6-[4-((S)-1-amino-propyl)-4-phenyl-cyclohexyloxy]-7-chloro-2H-isoquinolin-1-one 
• 1036378-61-6 1-Benzyloxy-6-(1-benzyl-4-phenyl-piperidin-4-yloxy)-7-chloro-isoquinoline 
• 1202072-40-9 5-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-adamantan-2-ylamine 
• 1036896-83-9 (3-endo)-syn-9-{[1-(benzyloxy)-7-chloroisoquinolin-6-yl]oxy}bicyclo[3.3.1] nonan-3-amine 

Relevant academic research and scientific papers

New substituted isoquinoline and isoquinolinone derivatives

The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES AS RHO KINASE INHIBITORS

The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

BI- AND POLYCYCLIC SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES

The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rh

6-SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES

The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosph

CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLONE DERIVATIVES

The invention relates to 6-substituted isoquinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and composit

CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES

The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

CYCLOHEXYLAMIN ISOQUINOLONE DERIVATIVES AS RHO-KINASE INHIBITORS

The invention relates to 6-cyclohexylamine-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I’) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.