923197-75-5

Basic information

• Product Name: (6-BROMO-1H-INDOL-2-YL)METHANOL
• Synonyms: (6-BROMO-1H-INDOL-2-YL)METHANOL;6-Bromo-2-(hydroxymethyl)-1H-indole;6-bromo-1H-Indole-2-methanol
• CAS NO: 923197-75-5
• Molecular Formula: C9H8BrNO
• Molecular Weight: 226.07
• Mol File: 923197-75-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 111-113°
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (6-BROMO-1H-INDOL-2-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (6-BROMO-1H-INDOL-2-YL)METHANOL(923197-75-5)
• EPA Substance Registry System: (6-BROMO-1H-INDOL-2-YL)METHANOL(923197-75-5)

Safety Data

• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 923197-75-5(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow powder or solid

Upstream product

• 16732-65-3 6-bromo-indole-2-carboxylic acid(Ref_.7.) 
• 372089-59-3 6-bromoindole 2-carboxylic acid methyl ester 
• 103858-53-3 ethyl 6-bromo-1H-indole-2-carboxylate 

Downstream Products

• 1382774-60-8 6-bromo-1-methyl-1H-indole-2-carbaldehyde 
• 53590-50-4 5-bromo-1H-indole-2-carbaldehyde 
• 1382774-46-0 4-(4-fluorophenethyl)-1-(1,1,5-trimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)piperazin-2-one 
• 1382774-64-2 tert-Butyl 7-(4-(4-fluorophenethyl)-2-oxopiperazin-1-yl)-1,1,5-trimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate 
• 105190-94-1 2-<2-(6-Amidinoindol-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid 
• 105191-12-6 6-bromo-1H-indole-2-carbaldehyde 

Relevant articles and documents

Synthesis of Indole- and Pyrrole-Fused Seven-Membered Nitrogen Heterocycles via Acid-Base Switchable Cyclization Involving Cleavage of Amide C?N Bonds

We report the method for synthesis of indole- and pyrrole-fused seven-membered nitrogen heterocycles by means of acid-base switchable cyclization reactions. The reactions involved cleavage of amide C?N bonds, chemoselective N-1 or C-3 acylation, and 1,4-M

Carbene-Catalyzed Enantioselective Aromatic N-Nucleophilic Addition of Heteroarenes to Ketones

The aromatic nitrogen atoms of heteroarylaldehydes are activated by carbene catalysts to react with ketone electrophiles. Multi-functionalized cyclic N,O-acetal products are afforded in good to excellent yields and optical purities. Our reaction involves the formation of an unprecedented aza-fulvene-type acylazolium intermediate. A broad range of N-heteroaromatic aldehydes and electron-deficient ketone substrates works effectively in this transformation. Several of the chiral N,O-acetal products afforded through this protocol exhibit excellent antibacterial activities against Ralstonia solanacearum (Rs) and are valuable in the development of novel agrichemicals for plant protection.

RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AS WELL AS PREPARATION METHOD AND USE THEREOF

The present invention relates to a Rho-associated protein kinase inhibitor of Formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and use thereof for the prevention or treatment of a disease mediated by the Rho-associated protein kinase (ROCK).