923281-72-5Relevant academic research and scientific papers
Palladium-Catalyzed Dehydrogenative Fluoroalkoxylation of Benzaldehydes
Jin, Long,Zhang, Xing-Long,Guo, Rui-Li,Wang, Meng-Yue,Gao, Ya-Ru,Wang, Yong-Qiang
supporting information, p. 1921 - 1927 (2021/03/08)
A direct and efficient palladium-catalyzed oxidative dehydrogenative fluoroalkoxylation of benzaldehydes is reported here for the first time. The method features mild reaction conditions, good tolerance of functional groups, and a broad substrate scope. The protocol employs the transient directing group strategy, thereby avoiding the additional installation and removal of directing groups, endowing the method with great advantages of atom and step economy. The approach should find broad applications in drug synthesis and discovery processes.
PIPERIDINE DERIVATIVE AS TACHYKININ RECEPTOR ANTAGONIST
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Page/Page column 95, (2010/11/25)
The present invention relates to a compounds represented by the formula. The compounds of the present invention have a superior tachykinin receptor antagonistic action, particularly a substance P receptor antagonistic action, and is useful as pharmaceutical agents, for example, tachykinin receptor antagonists, agents for the prophylaxis or treatment of lower urinary tract symptoms, gastrointestinal diseases or central nerve diseases.
