923289-02-5

Basic information

• Product Name: C₂₉H₃₇N₃O₈
• Synonyms: C₂₉H₃₇N₃O₈
• CAS NO: 923289-02-5
• Molecular Weight: 555.628
• Mol File: 923289-02-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₇N₃O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₇N₃O₈(923289-02-5)
• EPA Substance Registry System: C₂₉H₃₇N₃O₈(923289-02-5)

Safety Data

• Hazardous Substances Data: 923289-02-5(Hazardous Substances Data)

Upstream product

• 922726-51-0 4-nitro-benzoic acid (3S,5S)-5-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-pyrrolidin-3-yl ester 
• 31642-67-8 non-8-enoic acid 

Relevant articles and documents

Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors

Starting from the previously reported HCV NS3/4A protease inhibitor BILN 2061 (1), we have used a fast-follower approach to identify a novel series of HCV NS3/4A protease inhibitors in which (i) the P3 amino moiety and its capping group have been truncated, (ii) a sulfonamide is introduced in the P1 cyclopropyl amino acid, (iii) the position 8 of the quinoline is substituted with a methyl or halo group, and (iv) the ring size of the macrocycle has been reduced to 14 atoms. SAR analysis performed with a limited set of compounds led to the identification of N-{17-[8-chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy]-2,14-dioxo-3,15-diazatricyclo [13.3.0.0 [Bartenschlager, R.; Lohmann, V. J. Gen. Virol. 2000, 81, 1631; Vincent Soriano, Antonio Madejon, Eugenia Vispo, Pablo Labarga, Javier Garcia-Samaniego, Luz Martin-Carbonero, Julie Sheldon, Marcelle Bottecchia, Paula Tuma, Pablo Barreiro Expert Opin. Emerg. Drugs, 2008, 13, 1-19]]octadec-7-ene-4-carbonyl}(1-methylcyclopropyl)(1-methylcyclopropyl)sulfonamide 19l an extremely potent (Ki = 0.20 nM, EC50 = 3.7 nM), selective, and orally bioavailable dipeptide NS3/4A protease inhibitor, which has features attractive for further preclinical development.