92339-84-9

Basic information

• Product Name: 8-Aminoquinoline N-Oxide
• Synonyms: 8-Aminoquinoline N-Oxide;8-Aminoquinoline N-Oxide
• CAS NO: 92339-84-9
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Mol File: 92339-84-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 109.0 to 113.0 °C
• Boiling Point: 385°C at 760 mmHg
• Flash Point: 186.6°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 3.94E-06mmHg at 25°C
• Refractive Index: 1.649
• PKA: 2.25±0.10(Predicted)
• CAS DataBase Reference: 8-Aminoquinoline N-Oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Aminoquinoline N-Oxide(92339-84-9)
• EPA Substance Registry System: 8-Aminoquinoline N-Oxide(92339-84-9)

Safety Data

• Hazardous Substances Data: 92339-84-9(Hazardous Substances Data)

Usage

General Description

8-Aminoquinoline N-Oxide is a derivative of the aminoquinoline family with a molecular formula of C9H7NO. It is a nitrogen-containing compound containing a quinoline ring structure. This chemical has been studied for its potential use as an antimalarial agent, as well as for its role as a ligand in coordination chemistry. It is known to have varied biological activities and has been investigated for its potential cytotoxic and anticancer properties. Additionally, 8-Aminoquinoline N-Oxide has been studied for its potential use in organic electronic devices. Due to its diverse properties, this chemical remains an important target for research and development in pharmaceutical and materials science fields.

InChI:InChI=1/C9H8N2O/c10-8-5-1-3-7-4-2-6-11(12)9(7)8/h1-6H,10H2

Upstream product

• 1613-37-2 Quinoline N-oxide 
• 91-22-5 quinoline 
• 1620100-87-9 8-((4-methylphenyl)sulfonamido)-quinoline N-oxide 

Relevant articles and documents

Co(III)-Catalyzed C-H Amidation of Nitrogen-Containing Heterocycles with Dioxazolones under Mild Conditions

A cobalt(III)-catalyzed C-8 selective C-H amidation of quinoline N-oxide using dioxazolone as an amidating reagent under mild conditions is disclosed. The reaction proceeds efficiently with excellent functional group compatibility. The utility of the current method is demonstrated by gram scale synthesis of C-8 amide quinoline N-oxide and by converting this amidated product into functionalized quinolines. Furthermore, the developed catalytic method is also applicable for C-7 amidation of N-pyrimidylindolines and ortho-amidation of benzamides.