92356-73-5

Upstream product

• 1117-71-1 methyl-4-bromo-2-butenoate 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 67629-62-3 methyl 4-(diethylphosphono)crotonate 
• 74-88-4 methyl iodide 
• 623-43-8 crotonic acid methyl ester 

Downstream Products

• 33356-70-6 6-(4-dimethylamino-phenyl)-2-phenyl-3,6-dihydro-2H-[1,2]oxazine-3-carboxylic acid methyl ester 
• 92356-77-9 (2E,4E)-5-(4-(dimethylamino)phenyl)-1-(piperidin-1-yl)penta-2,4-dien-1-one 
• 443360-67-6 (2E,4E)-5-(4-Dimethylamino-phenyl)-penta-2,4-dienoyl chloride 
• 15542-38-8 (2E,4E)-5-[4-(dimethylamino)phenyl]-2,4-pentadienoic acid 

Relevant academic research and scientific papers

Synthetic and spectroscopic studies of structural analogs of piper amides - The 5-aryl-2E,4E-pentadienamides

The methyl esters and piperidides of fourteen 5-aryl-2E,4E-pentadienoic acids have been synthesized starting from the corresponding aryl aldehydes.

Substituent Effects on Carbon-13 NMR Chemical Shifts of Side-chain Carbons in 5-Aryl-2E,4E-pentadienoic Acid Derivatives

The 13C NMR spectra of two series of 5-aryl-2E,4E-pentadienoic acid derivatives, viz. the methyl esters and piperidides have been determined.The chemical shifts of C-2 and C-4 show very good correlations with the Hammett ?+-constants for all the substituents investigated, except for the para-nitro group which is capable of excerting a strong -R effect.A possible explanation for this has been advanced.Hammett correlations between substituents and the chemical shifts of both C-3 and C-5 carbons using ?0 parameters are less satisfactory.A reverse chemical shift effect has been observed for these two centres.