923586-82-7Relevant academic research and scientific papers
Sequence-specific DNA binding by noncovalent peptide-tripyrrole conjugates
Blanco, Juan B.,Dodero, Veronica I.,Vazquez, M. Eugenia,Mosquera, Manuel,Castedo, Luis,Mascarenas, Jose L.
, p. 8210 - 8214 (2006)
To join the groove: Equipping basic-region bZIP peptides with a noncovalent heterodimerizing unit allows their major-groove DNA-binding capability to be triggered upon addition of appropriate external ligands that bind into adjacent minor-groove sites. The resulting noncovalent hybrids bind relatively long DNA sites with good affinity and very high specificity. (Figure Presented).
