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• 201230-82-2 carbon monoxide 

Relevant academic research and scientific papers

Oxidative synthesis of quinazolinones and benzothiadiazine 1,1-dioxides from 2-aminobenzamide and 2-aminobenzenesulfonamide with benzyl alcohols and aldehydes

An interesting procedure for the zinc-catalyzed oxidative transformation of ready available 2-aminobenzamide, 2-aminobenzenesulfonamide with benzyl alcohols has been developed. Various quinazolinones and benzothiadiazine 1,1-dioxides were prepared in moderate to good yields under identical conditions. The reactions of both aromatic aldehydes and aliphatic aldehydes with 2-aminobenzamide under catalyst free conditions were described as well. In water media, the products were formed in good yields.

Synergistic catalysis on Fe-N: X sites and Fe nanoparticles for efficient synthesis of quinolines and quinazolinones via oxidative coupling of amines and aldehydes

In this paper, we developed a reusable heterogeneous non-precious iron nanocomposite comprising metallic Fe-Fe3C nanoparticles and Fe-Nx sites on N-doped porous carbon, which allows for highly efficient synthesis of quinolines and quinazolinones via oxidative coupling of amines and aldehydes using H2O2 as the oxidant in aqueous solution under mild conditions. A set of quinazolines and quinazolinones were synthesized in high yields with a broad substrate scope and good tolerance of functional groups. Characterization and control experiments disclose that a synergistic effect between the metallic Fe nanoparticles and built-in Fe-Nx sites is primarily responsible for the outstanding catalytic performance. Furthermore, the iron nanocomposite could be readily recovered for successive use without appreciable loss in catalytic activity and selectivity. This work provides an expedient and sustainable method to access pharmaceutically relevant N-heterocycles.

Synthesis method of 2-substituted heterocyclic ring quinazolinone compounds

The invention discloses a synthesis method of 2-substituted heterocyclic ring quinazolinone compounds. The reaction equation is as shown in the description, wherein a heterocyclic ring vinyl compoundin the reaction equation is as shown in the description. The synthesis method has the beneficial effects that (1) the reaction is efficient, the yield is high, reaction efficiency is higher after reaction is amplified, and the method is suitable for large-scale industrialized production; (2) the heterocyclic ring vinyl compound is selected as the raw material, is low in cost and easy to obtain, and is more economical; (3) the synthesis process is easy to operate, and the obtained product is easy for aftertreatment; and (4) the method is not performed at high temperature and high pressure, thereaction condition is mild and reaction time is short.

Palladium-catalyzed carbonylative synthesis of quinazolinones from 2-aminobenzamide and aryl bromides

C from CO! A straightforward procedure for the carbonylative synthesis of quinazolinones from readily available 2-aminobenzamide and aryl bromides has been developed. In the presence of a palladium catalyst, various quinazolinones were produced in moderate to excellent yields. Remarkably, no chromatography was needed for purification (see scheme). Copyright