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Upstream product

• 118-48-9 isatoic anhydride 
• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 28144-70-9 anthranilic acid amide 
• 612-24-8 o-nitrobenzonitrile 

Relevant academic research and scientific papers

Glucose as an Eco-Friendly Reductant in a One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco-friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one-pot sequences involving glucose as a reductant.

Application of SBA-Pr-SO3H in the synthesis of 2,3-dihydroquinazoline-4(1H)-ones: characterization, UV–Vis investigations and DFT studies

An efficient one-pot synthesis of 2,3-dihydroquinazoline-4(1H)-one derivatives 4a–l is described using SBA-Pr-SO3H as a heterogeneous acid catalyst. The present methodology resulted in various derivatives of 2,3-dihydroquinazoline-4(1H)-one in

Synthesis of 2,3-dihydroquinazolinones and quinazolin-4(3H)-ones catalyzed by graphene oxide nanosheets in an aqueous medium: "on-water" synthesis accompanied by carbocatalysis and selective C-C bond cleavage

Graphene oxide (GO) nanosheet catalyzed new and straightforward strategies for the construction of 2,3-dihydroquinazolinones and quinazolin-4(3H)-ones starting from anthranilamide (2-aminobenzamide) and an aldehyde/ketone in aqueous medium at room temperature have been realized. This catalyst is also found to be efficient for the expedient construction of quinazolin-4(3H)-ones starting from anthranilamide and a β-ketoester/1,3-diketone following selective C-C bond cleavage of the β-ketoester/1,3-diketone at an elevated temperature under metal and oxidant free conditions.

Pentafluorophenylammonium triflate as a suitable and effective metal-free catalyst for the synthesis of quinazoline derivatives via one-pot multicomponent method

A simple and facile synthesis of highly functionalized quinazoline derivatives has been successfully developed by treatment of aldehydes, ammonium acetate, and 2-aminoaryl ketones or isatoic anhydride under reflux conditions in the presence of a pentafluorophenylammonium triflate (PFPAT) organocatalyst. These catalytic condensation reactions represent green chemical processes, while the PFPAT organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction mixtures.

Efficient synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones in the presence of nanocomposites under microwave irradiation

The preparation of quinazolinones has been developed by the condensation of aromatic aldehydes and 2-aminobenzamide in the presence of transition metal-CNTs nanocomposites as novel and recyclable catalyst under microwave and solvent-free conditions. This methodology provides a high speed path for the green and mild synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones with high structural diversity. The present methodology has advantages such as high activity and reusability of catalysts, heterogeneous nature of catalysts, no use of hazardous organic solvents and green conditions.

Application of the ultrasound in the mild synthesis of substituted 2,3-dihydroquinazolin-4(1H)-ones catalyzed by heterogeneous metal-MWCNTs nanocomposites

A practical method were applied successfully to synthesize mono- and disubstituted dihydroquinazolinones through three-component condensation of isatoic anhydride, primary amines or ammonium acetate with aromatic aldehydes in the presence of some transiti

Microwave-accelerated three components cyclocondensation in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones promoted by Cu-CNTs

Cu-CNTs efficiently catalyzes condensation reaction of isatoic anhydride, aldehydes, and primary amines or ammonium acetate to afford the corresponding 2,3-dihydroquinazolin-4(1H)-one derivatives successfully in high yield. The protocol proves to be effic

Synthesis of 2-arylquinazolin-4(3H)-one derivatives catalyzed by iodine in [bmim+][BF-4]

Controlling selectivity of the reactions of aromatic aldehydes and 2-aminobenzamide in ionic liquid catalyzed by iodine at either room temperature or at 80°C under nitrogen resulted in the synthesis of (E)-Schiff bases, 2,3-dihydro-2-arylquinazolin-4(1H)-one and 2-arylquinazolin-4(3H)-one derivatives, in excellent yields. Taylor & Francis Group, LLC.

Synthesis of some novel 2-aryl-substituted 2,3-dihydroquinazolin-4(1 H)-ones under solvent-free conditions using MCM-41-SO3H as a highly efficient sulfonic acid

MCM-41-SO3H, ordered mesoporous silica material MCM-41 with covalently anchored sulfonic acid groups located inside the mesochannels, was used as an acid catalyst for the rapid and green synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives

An efficient one-pot solvent-free synthesis of 2,3-dihydroquinazoline-4(1H) -ones via Al/Al2O3 nanoparticles

An efficient one-pot, solvent-free method is reported for the synthesis of 2-phenyl-2,3-dihydroquinazoline-4(1H)-one as well as its o-Cl, o-OMe, m-Br, m-NO2, p-OH, p-NO2, p-CN, p-PhCH2O, p-Cl, p-F, p-Br, p-Me, and o,m-dich