923929-10-6

Basic information

• Product Name: 5-Bromo-4-methyl-N-nitropyridin-2-amine
• Synonyms: 5-Bromo-4-methyl-N-nitropyridin-2-amine;5-Bromo-4-methyl-N-nitropyridine-2-amine;N-(5-broMo-4-Methylpyridin-2-yl)nitraMide
• CAS NO: 923929-10-6
• Molecular Formula: C6H6BrN3O2
• Molecular Weight: 232.03
• Product Categories: CHIRAL CHEMICALS
• Mol File: 923929-10-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 162 ºC
• Boiling Point: 332.4ºC at 760 mmHg
• Flash Point: 154.8ºC
• Appearance: /
• Density: 1.773
• Vapor Pressure: 0.000146mmHg at 25°C
• Refractive Index: 1.652
• CAS DataBase Reference: 5-Bromo-4-methyl-N-nitropyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-4-methyl-N-nitropyridin-2-amine(923929-10-6)
• EPA Substance Registry System: 5-Bromo-4-methyl-N-nitropyridin-2-amine(923929-10-6)

Safety Data

• Hazardous Substances Data: 923929-10-6(Hazardous Substances Data)

Usage

General Description

5-Bromo-4-methyl-N-nitropyridin-2-amine is a chemical compound with the molecular formula C6H6BrN3O2. It is a nitroaromatic compound that contains a bromine atom, a methyl group, and a nitro group attached to a pyridine ring. 5-Bromo-4-methyl-N-nitropyridin-2-amine is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is also utilized in research and development processes in the chemical industry. The presence of the nitro group makes 5-Bromo-4-methyl-N-nitropyridin-2-amine potentially harmful if ingested, inhaled, or comes into contact with the skin, and appropriate safety measures should be taken when handling it.

InChI:InChI=1/C6H6BrN3O2/c1-4-2-6(9-10(11)12)8-3-5(4)7/h2-3H,1H3,(H,8,9)

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 98198-48-2 2-amino-5-bromo-4-methylpyridine 
• 33245-30-6 4-methyl-2-nitraminopyridine 

Relevant articles and documents

Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses

Bioisosteric deaza analogues of 6-methyl-9-β-d-ribofuranosylpurine, a hydrophobic analogue of adenosine, were synthesized and evaluated for antiviral activity. Whereas the 1-deaza and 3-deaza analogues were essentially inactive in plaque assays of infectivity, a novel 7-deaza-6-methyl-9-β-d- ribofuranosylpurine analogue, structurally related to the natural product tubercidin, potently inhibited replication of poliovirus (PV) in HeLa cells (IC50 = 11 nM) and dengue virus (DENV) in Vero cells (IC50 = 62 nM). Selectivity against PV over cytotoxic effects to HeLa cells was >100-fold after incubation for 7 h. Mechanistic studies of the 5′-triphosphate of 7-deaza-6-methyl-9-β-d-ribofuranosylpurine revealed that this compound is an efficient substrate of PV RNA-dependent RNA polymerase (RdRP) and is incorporated into RNA mimicking both ATP and GTP.

Method of preparation of nitroaminopyridine compounds

A method of preparing an intermediate which is useful for the preparation of azaindole derivatives.