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Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-4-methyl-N-nitropyridin-2-amine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicine and healthcare.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Bromo-4-methyl-N-nitropyridin-2-amine serves as an essential component in the production of certain pesticides and herbicides. Its incorporation into these products enhances their effectiveness in controlling pests and weeds, thereby improving crop yields and agricultural productivity.
Used in Dye Industry:
5-Bromo-4-methyl-N-nitropyridin-2-amine is utilized as a building block in the synthesis of various dyes. Its presence in these dyes imparts specific color characteristics and properties, making it valuable for applications in textiles, printing, and other industries that rely on colorants.
Used in Chemical Research and Development:
5-Bromo-4-methyl-N-nitropyridin-2-amine plays a significant role in the chemical research and development process. Its unique chemical properties make it a valuable compound for studying various reactions and mechanisms, leading to the discovery of new chemical processes and applications.
Safety Precautions:
Due to the presence of the nitro group, 5-Bromo-4-methyl-N-nitropyridin-2-amine can be potentially harmful if ingested, inhaled, or comes into contact with the skin. It is crucial to follow appropriate safety measures when handling 5-Bromo-4-methyl-N-nitropyridin-2-amine, including the use of personal protective equipment and proper disposal methods to minimize risks to human health and the environment.

InChI:InChI=1/C6H6BrN3O2/c1-4-2-6(9-10(11)12)8-3-5(4)7/h2-3H,1H3,(H,8,9)

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 98198-48-2 2-amino-5-bromo-4-methylpyridine 
• 33245-30-6 4-methyl-2-nitraminopyridine 

Relevant academic research and scientific papers

Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses

Bioisosteric deaza analogues of 6-methyl-9-β-d-ribofuranosylpurine, a hydrophobic analogue of adenosine, were synthesized and evaluated for antiviral activity. Whereas the 1-deaza and 3-deaza analogues were essentially inactive in plaque assays of infectivity, a novel 7-deaza-6-methyl-9-β-d- ribofuranosylpurine analogue, structurally related to the natural product tubercidin, potently inhibited replication of poliovirus (PV) in HeLa cells (IC50 = 11 nM) and dengue virus (DENV) in Vero cells (IC50 = 62 nM). Selectivity against PV over cytotoxic effects to HeLa cells was >100-fold after incubation for 7 h. Mechanistic studies of the 5′-triphosphate of 7-deaza-6-methyl-9-β-d-ribofuranosylpurine revealed that this compound is an efficient substrate of PV RNA-dependent RNA polymerase (RdRP) and is incorporated into RNA mimicking both ATP and GTP.

An alternate route to 2-amino-3-nitro-5-bromo-4-picoline: Regioselective pyridine synthesis via 2-nitramino-picoline intermediate

The 2-nitramino functionality in 2-nitramino-4-picoline was successfully exploited not only as a protecting group but also as a directional handle to afford an efficient, atom-economic, and regioselective synthesis of 2-amino-5-bromo-3-nitro-4-picoline (4), a precursor for a drug candidate in development.

Method of preparation of nitroaminopyridine compounds

A method of preparing an intermediate which is useful for the preparation of azaindole derivatives.