923956-13-2

Upstream product

• 4949-44-4 ethyl propanoylacetate 
• 204195-08-4 (2S)-2,6-dimethyl-hept-6-enal 
• 187527-25-9 (-)-(5S)-5,7-bis{[tert-butyl(dimethyl)silyl]oxy}-4,4-dimethylheptan-3-one 
• 923956-21-2 (3S,6R,7S,8S)-3-(tert-butyldimethylsilanyloxy)-4,4,6,8,12-pentamethyl-5-oxo-7-(2,2,2-trichloethoxycarbonyloxy)tridec-12-enoic acid (1S,2E,5S)-2-methyl-3-phenyl-5-vinylcyclopent-2-enyl ester 
• 923956-16-5 carbonic acid 1-[4,6-bis(tert-butyldimethylsilanyloxy)-1,3,3-trimethyl-2-oxohexyl]-2,6-dimethyl-1-hept-6-enyl ester 2,2,2-trichloroethyl ester 
• 923956-19-8 (3S,6R,7S,8S)-3-(tert-butyldimethylsilanyloxy)-4,4,6,8,12-pentamethyl-5-oxo-7-(2,2,2-trichloroethoxycarbonyloxy)tridec-12-enoic acid 
• 923956-17-6 carbonic acid 1-[4-(tert-butyldimethylsilanyloxy)-6-hydroxy-1,3,3-trimethyl-2-oxohexyl]-2,6-dimethyl-1-hept-6-enyl ester 2,2,2-trichloroethyl ester 
• 923956-18-7 C₂₇H₄₇Cl₃O₆Si 
• 923956-15-4 (3S,6R,7S,8S)-1,3-bis(tert-butyldimethylsilanyloxy)-7-hydroxy-4,4,6,8,12-pentamethyltridec-12-en-5-one 
• 923956-09-6 (1R,2S,3E)-3-methyl-4-phenyl-2-triethylsilanyloxycyclopent-3-enecarboxylic acid ethyl ester 
• 923956-20-1 (1S,2E,5S)-triethyl-(2-methyl-3-phenyl-5-vinylcyclopent-2-enyloxy)silane 
• 923956-10-9 (1R,2S,3E)-3-methyl-4-phenyl-2-triethylsilanyloxycyclopent-3-enecarbaldehyde 
• 923956-08-5 (1R,2S,3E)-2-acetoxy-3-methyl-4-phenylcyclopent-3-enecarboxylic acid ethyl ester 
• 923956-43-8 (1R,2S,3E)-2-hydroxy-3-methyl-4-phenylcyclopent-3-enecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

CONFORMATIONALLY RESTRAINED EPOTHILONE ANALOGUES AS ANTI-LEUKEMIC AGENTS

A method for synthesizing anti-leukemic epothilone analogues includes rigidifying a region between the macrolactone ring and the aromatic side-chain. The anti-leukemic compositions are non-naturally occurring epothilone analogue that are rigidified between the macrolactone ring and the aromatic side-chain.

Total synthesis and selective activity of a new class of conformationally restrained epothilones

Stereoselective total syntheses of two novel conformationally restrained epothilone analogues are described. Evans asymmetric alkylation, Brown allylation, and a diastereoselective aldol reaction served as the key steps in the stereoselective synthesis of

EPOTHILONE ANALOGUES

Epothilone analogues include a molecular scaffold which holds at least one segment of epothilone in a predetermined orientation and which rigidities a region between the macrolactone ring and the aromatic side-chain.