923956-39-2Relevant academic research and scientific papers
Total synthesis and selective activity of a new class of conformationally restrained epothilones
Alhamadsheh, Mamoun M.,Gupta, Shuchi,Hudson, Richard A.,Perera, Lalith,Tillekeratne, L. M. Viranga
, p. 570 - 581 (2008/12/22)
Stereoselective total syntheses of two novel conformationally restrained epothilone analogues are described. Evans asymmetric alkylation, Brown allylation, and a diastereoselective aldol reaction served as the key steps in the stereoselective synthesis of
CONFORMATIONALLY RESTRAINED EPOTHILONE ANALOGUES AS ANTI-LEUKEMIC AGENTS
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Page/Page column 25-26; Sheet 3/13, (2008/12/04)
A method for synthesizing anti-leukemic epothilone analogues includes rigidifying a region between the macrolactone ring and the aromatic side-chain. The anti-leukemic compositions are non-naturally occurring epothilone analogue that are rigidified between the macrolactone ring and the aromatic side-chain.
EPOTHILONE ANALOGUES
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Page/Page column 40; 8/22, (2008/06/13)
Epothilone analogues include a molecular scaffold which holds at least one segment of epothilone in a predetermined orientation and which rigidities a region between the macrolactone ring and the aromatic side-chain.
