923969-76-0Relevant academic research and scientific papers
Penicillins as β-lactamase-dependent prodrugs: Enabling role of a vinyl ester exocyclic to the lactam ring
Ruddle, Carol C.,Smyth, Timothy P.
, p. 2332 - 2333 (2007/10/03)
Incorporation of a vinyl ester exocyclic to the β-lactam ring of a penicillin nucleus enables this to act as a β-lactamase-dependent prodrug - rapid release of the (unactivated) alkoxy component of the vinyl ester is triggered by enzyme-catalysed hydrolys
