92407-86-8Relevant academic research and scientific papers
Synthesis and anticancer activity studies of indolylisoxazoline analogues
Chaitanya,Reddy, P.O. Venkataramana,Nikhil, Kumar,Kumar, Anil,Shah, Kavita,Kumar, Dalip
supporting information, p. 2842 - 2845 (2018/08/03)
A new library of thirteen indolylisoxazolines 6a–m has been synthesized by the treatment of indolylchalcones with hydroxylamine hydrochloride. Evaluation of anticancer activity of indolylisoxazolines 6a–m led to the identification of potent compounds 6c–d
Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives
Na, Young-Min,Le Borgne, Marc,Pagniez, Fabrice,Le Baut, Guillaume,Le Pape, Patrice
, p. 75 - 87 (2007/10/03)
A series of 1-benzyl-3-(imidazol-1-ylmethyl)indole derivatives 35-46 were prepared under mild reaction conditions and tested for their antifungal activity. Pharmacomodulation at N1, C2 and C5 of the indole ring and at the level of the alkyl chain (R1) was carried out starting from the corresponding 3-acylindoles 6, 7 or 3-formylindoles 11-22. Target imidazolyl compounds 35-46 were obtained in satisfactory yields by CO2 elimination from the intermediate carbamates. All of the compounds were evaluated in vitro against two human fungal pathogens, Candida albicans (CA980001) and Aspergillus fumigatus (AF980003); amphotericin B, fluconazole and itraconazole were used as references. Seven out of 27 compounds (35b, 35e, 35g, 35h, 36a, 38a and especially 40a) exerted significant antifungal activity against C. albicans, with MIC in the range of 1-6 μg mL-1. As regards inhibitory activity against A. fumigatus, the MIC figures of most of our compounds were in excess of 20 μg mL-1 in contrast to the reference drugs, amphotericin B and itraconazole, whose MIC90 and MIC80 values were 0.14 and 0.50 μg mL-1, respectively. The most potent compound, 45a, exhibited MIC value (8±1 μg mL-1) 16-fold higher than that of itraconazole.
Syntheses and in vitro antimycotic activities of 1-benzyl-3-(1-imidazolylmethyl)indoles
Cavrini,Gatti,Roveri,Cesaroni,Mazzoni,Fiorentini
, p. 662 - 668 (2007/10/02)
Syntheses of seventeen 1-benzyl-3-(1-imidazolylmethyl)indoles with substituents at the benzyl moiety and at the indole C-2 position are described. The compounds were tested for their antifungal activities in vitro determination of the minimum inhibitory concentration (MIC). Three compounds exhibited appreciable activities against Cr. neoformans.
