92410-30-5Relevant academic research and scientific papers
SPIRO-SUBSTITUTED AZACYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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, (2008/06/13)
The present invention is directed to spiro-substituted azacycles of the Formula 1: STR1 (wherein R 1, l, m, Q, W, X, Y, and Z are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
Possible Antineoplastic Agents: Part VIII - Synthesis and Antineoplastic Activity of 5-N-Substituted 3-p-Substituted-phenylglutaramic Acids and 5-N-Substituted 2-Benzenesulphonyl-3-phenyl-L-glutamines
De, A. U.,Mazumdar, Anjali,Jha, Tarun,Debnath, Asim Kumar
, p. 97 - 98 (2007/10/02)
A few 5-N-substituted 3-p-substituted-phenylglutaramic acids (II) and 5-N-substituted 2-benzenesulphonyl-3-phenyl-L-glutamines (V) have been synthesized as structural variants of glutamic acid and evaluated for their activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice.Quantitative structure activity relationship (QSAR) has been determined employing de novo model to the compounds.The glutaramic acids (II) exhibit better correlation and antineoplastic activity than the glutamines (V).
