924282-39-3

Upstream product

• 169895-52-7 (E)-3-[(2R,3S,4aR,6R,8S,8aS)-8-Benzyloxy-6-(3-benzyloxy-propyl)-3-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-acrylic acid methyl ester 
• 79271-56-0 triethylsilyl trifluoromethyl sulfonate 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 924282-34-8 3-[2-methyl-3-triethylsilanyloxy-8-triisopropylsilanyloxy-6-(3-triisopropylsilanyloxy-propyl)-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester 
• 924282-36-0 3-[2-methyl-3-triethylsilanyloxy-8-triisopropylsilanyloxy-6-(3-triisopropylsilanyloxy-propyl)-octahydro-pyrano[3,2-b]pyran-2-yl]-propan-1-ol 
• 924282-31-5 3-[8-benzyloxy-6-(3-benzyloxy-propyl)-2-methyl-3-triethylsilanyloxy-octahydro-pyrano[3,2-b]pyran-2-yl]-acrylic acid methyl ester 
• 924282-45-1 tert-butyl-{1-[1-(4-methoxy-benzyloxy)-4-(2,4,6-trichloro-benzyloxy)-butyl]-1-methyl-allyloxy}-dimethyl-silane 
• 924282-38-2 4-(4-methoxy-benzyloxy)-3-methyl-7-(2,4,6-trichloro-benzyloxy)-hept-1-en-3-ol 
• 924282-30-4 3-(tert-butyl-dimethyl-silanyloxy)-3-methyl-7-(2,4,6-trichloro-benzyloxy)-hept-1-en-4-ol 
• 924282-29-1 3-[2-methyl-3-triethylsilanyloxy-8-triisopropylsilanyloxy-6-(3-triisopropylsilanyloxy-propyl)-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid 

Downstream Products

• 924282-43-9 8-{2-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[3-(2,4,6-trichloro-benzyloxy)-propyl]-but-3-enyloxy}-5a-methyl-4-triisopropylsilanyloxy-2-(3-triisopropylsilanyloxy-propyl)-9-vinyl-dodecahydro-1,5,10-trioxa-cyclohepta[b]naphthalene 
• 924282-44-0 C₅₅H₉₇Cl₃O₈Si₃ 
• 924282-40-6 3-[3-hydroxy-2-methyl-8-triisopropylsilanyloxy-6-(3-triisopropylsilanyloxy-propyl)-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid 2-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[3-(2,4,6-trichloro-benzyloxy)-propyl]-but-3-enyl ester 

Relevant academic research and scientific papers

A convergent approach to the formal total synthesis of hemibrevetoxin B

A convergent synthesis of the key synthetic intermediate of hemibrevetoxin B was achieved via the intramolecular allylation of an α-chloroacetoxy ether and subsequent ring-closing metathesis.

Formal total synthesis of hemibrevetoxin B via the intramolecular allylation followed by ring-closing metathesis

A formal total synthesis of hemibrevetoxin B (1) is described. Intramolecular allylation of α-chloroacetoxy ether 10, prepared from carboxylic acid 11 and alcohol 12, was carried out with MgBr2·OEt2 to give 27. Ring-closing metathesi