924309-78-4

Basic information

• Product Name: Benzeneacetic acid, 4-amino-3-(1-methylethyl)-, ethyl ester
• CAS NO: 924309-78-4
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Mol File: 924309-78-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 4-amino-3-(1-methylethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 4-amino-3-(1-methylethyl)-, ethyl ester(924309-78-4)
• EPA Substance Registry System: Benzeneacetic acid, 4-amino-3-(1-methylethyl)-, ethyl ester(924309-78-4)

Safety Data

• Hazardous Substances Data: 924309-78-4(Hazardous Substances Data)

Upstream product

• 5445-26-1 ETHYL 4-NITROPHENYLACETATE 
• 148582-46-1 ethyl (3-isopropyl-4-nitrophenyl)acetate 

Downstream Products

• 924309-82-0 (3-isopropyl-4-[N'-(2-methylphenyl)ureido]phenyl)acetic acid 

Relevant articles and documents

Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists

A series of benzoic acid derivatives was synthesized as VLA-4 antagonists. Introduction of chlorine or bromine into the 3-position on the central benzene of the diphenylurea portion as in lead compound 2 led to improvement in the pharmacokinetic properties. In particular, 12l demonstrated an acceptable plasma clearance and bioavailability in mice and rats as well as dogs (mice, CL = 18.5 ml/min/kg, F = 28 %; rats, CL = 5.2 ml/min/kg, F = 36 %; dogs, CL = 3.6 ml/min/kg, F = 55 %). Additionally, 12l exhibited potent activity with an IC50 value of 0.51 nM and efficacy by oral administration at a dosage of 10 mg/kg in a rat pleurisy model.