924309-89-7

Basic information

• Product Name: methyl (4-nitro-3-trimethylsilylethynylphenyl)acetate
• Synonyms: methyl (4-nitro-3-trimethylsilylethynylphenyl)acetate
• CAS NO: 924309-89-7
• Molecular Weight: 291.379
• Mol File: 924309-89-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (4-nitro-3-trimethylsilylethynylphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (4-nitro-3-trimethylsilylethynylphenyl)acetate(924309-89-7)
• EPA Substance Registry System: methyl (4-nitro-3-trimethylsilylethynylphenyl)acetate(924309-89-7)

Safety Data

• Hazardous Substances Data: 924309-89-7(Hazardous Substances Data)

Upstream product

• 185200-33-3 methyl (3-bromo-4-nitrophenyl)acetate 
• 1066-54-2 trimethylsilylacetylene 
• 150529-73-0 methyl 2-(3-bromophenyl)acetatee 
• 1878-67-7 3-Bromophenylacetic acid 

Downstream Products

• 924309-90-0 methyl (3-ethynyl-4-nitrophenyl)acetate 
• 924309-81-9 (3-ethyl-4-[N'-(2-methylphenyl)ureido]phenyl)acetic acid 
• 924309-77-3 methyl (4-amino-3-ethylphenyl)acetate 

Relevant articles and documents

Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists

A series of benzoic acid derivatives was synthesized as VLA-4 antagonists. Introduction of chlorine or bromine into the 3-position on the central benzene of the diphenylurea portion as in lead compound 2 led to improvement in the pharmacokinetic properties. In particular, 12l demonstrated an acceptable plasma clearance and bioavailability in mice and rats as well as dogs (mice, CL = 18.5 ml/min/kg, F = 28 %; rats, CL = 5.2 ml/min/kg, F = 36 %; dogs, CL = 3.6 ml/min/kg, F = 55 %). Additionally, 12l exhibited potent activity with an IC50 value of 0.51 nM and efficacy by oral administration at a dosage of 10 mg/kg in a rat pleurisy model.