924312-41-4

Upstream product

• 118992-89-5 [4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl]methanol 
• 124-63-0 methanesulfonyl chloride 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 589-29-7 p-xylylene glycol 

Downstream Products

• 1367598-15-9 C₃₄H₄₀N₂O₄ 
• 1367594-61-3 (4R,4aS,6R,7R,7aR,12bS)-6-(((4-((2H-tetrazol-5-yl)methyl)benzyl)oxy)methyl)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline 
• 1367598-09-1 C₃₉H₅₅NO₅Si 
• 278793-22-9 N-[(E)-2-(4-(hydroxymethyl)benzyloxyimino)ethanonyl]bornane-10,2-sultam glutaric acid monoester 
• 278793-27-4 N-[(E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanonyl]bornane-10,2-sultam 
• 278793-20-7 N-[(E)-2-[4-(hydroxymethyl)benzyloxyimino]ethanonyl]bornane-10,2-sultam 
• 278793-19-4 methyl (E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanate 
• 278793-18-3 N-[4-(t-butyldimethylsiloxymethyl)benzyloxy]phthalimide 

Relevant academic research and scientific papers

Diastereoselective solid-phase radical addition to oxime ether anchored to polymer support

Stereocontrol in radical reactions of oxime ether anchored to polymer support was studied. Highly diastereoselective solid-phase radical reaction was achieved by using triethylborane and diethylzinc as a radical initiator at low reaction temperature, providing a novel method for the synthesis of the α-amino acid derivatives with excellent diastereoselectivities.

BUPRENORPHINE ANALOGS

The present invention is directed to Buprenorphine Analog compounds of the Formula (I), Formula (IA) or Formula (IB) shown below, wherein R1, R2, R8, R3a, R3b, G, X, Z and Y are as defined herein. Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.

PYRIDONE COMPOUND

An active ingredient is a compound represented by the general formula [I]: [wherein R1 and R2 represent a lower alkyl group, a C3-6 cycloalkyl group or the like, X1 and X2 represent methine, an Ar-Ys