92439-13-9Relevant academic research and scientific papers
Cu-catalyzed consecutive hydroxylation and aerobic oxidative cycloetherification under microwave conditions: Entry to 2-arylbenzofuran-3-carboxylic acids
Xu, Tianlong,Zhang, Ensheng,Wang, Dejian,Wang, Yan,Zou, Yong
, p. 4313 - 4324 (2015)
A convenient one-pot synthesis of 2-arylbenzofuran-3-carboxylic acids from (E)-2-(2-bromophenyl)-3-phenylacrylic acids via Cu-catalyzed consecutive hydroxylation and aerobic oxidative cycloetherification under microwave conditions has been developed. This protocol employed the reagent combination of Cu(OAc)2, 1,10-phen, and KOH in DMSO/H2O (1:1), all of which are cost-effective, readily available, and easily removable from the reaction mixture. Utilizing this synthetic protocol, various 2-arylbenzofuran-3-carboxylic acids as well as the natural product moracin M have been synthesized in satisfactory yields under mild conditions.
