92449-40-6Relevant academic research and scientific papers
o-aminobiphenyl compound synthesis method
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Paragraph 0063; 0064; 0065, (2018/04/02)
The invention relates to an o-aminobiphenyl compound synthesis method, which comprises: carrying out a reaction on an o-nitroaromatic formic acid compound, an alkali and a solvent, removing water, adding substituted halobenzene, a catalyst and a ligand, carrying out a reaction, or carrying out a reaction on a pre-prepared o-nitroaromatic formate, substituted halobenzene, a catalyst, a ligand and a solvent, and carrying out post-treatment to obtain the o-aminobiphenyl compound. According to the present invention, the o-aminobiphenyl compound is synthesized by using the easily available or easily prepared o-nitroaromatic formate and the substituted halobenzene as the raw material through the one-step method without the use of hydrogen and other hazardous reducing agents, such that the coupling and nitro reduction continuous reaction is achieved, and the advantages of new reaction, safety, high efficiency, simple operation and low cost are provided.
Arylalkene synthesis via decarboxylative cross-coupling of alkenyl halides
Tang, Jie,Goossen, Lukas J.
supporting information, p. 2664 - 2667 (2014/06/09)
A bimetallic catalyst system generated from readily available palladium(II) and copper(I) salts, 1,10-phenanthroline and tri-1-naphthylphosphine was found to efficiently mediate the decarboxylative cross-coupling of alkenyl bromides and chlorides with aromatic carboxylates. It allows the regiospecific synthesis of a broad range of aryl- and heteroarylalkenes in high yields.
Decarboxylative cross-coupling of mesylates catalyzed by copper/palladium systems with customized imidazolyl phosphine ligands
Song, Bingrui,Knauber, Thomas,Goo?en, Lukas J.
supporting information, p. 2954 - 2958 (2013/04/11)
The activation of the inert C-O bonds in mesylates through the use of a new class of imidazolyl phosphines allows the decarboxylative coupling of aryl mesylates as well as polysubstituted alkenyl mesylates. Variation of the ligands leads to two complementary methods providing the corresponding biaryls and polysubstituted olefins in good yields. Copyright
Low-Temperature Ag/Pd-catalyzed decarboxylative cross-coupling of aryl trflates with aromatic carboxylate salts
Goossen, Lukas J.,Lange, Paul P.,Rodriguez, Nuria,Linder, Christophe
supporting information; experimental part, p. 3906 - 3909 (2010/07/03)
Chemical Equation Presented At 50°C lower than the best known copper catalysts, a catalytic silver(I)/ palladium(II) system allows the decarboxylative cross-coupling of arenecarboxylates with aryl triflates at temper-atures as low as 120°C. Remarkably, polychlorinated and many heterocyclic arenecarboxylates are converted for the first time in high yields. FG = functional group.
Pd-catalyzed decarboxylative Heck vinylation of 2-nitrobenzoates in the presence of CuF2
Goossen, Lukas J.,Zimmermann, Bettina,Knauber, Thomas
supporting information; experimental part, (2010/08/19)
A new protocol for the decarboxylative Heck vinylation of benzoic acids is disclosed. In the presence of a catalyst system generated in situ from Pd(OAc)2 (2 mol %), CuF2 (2 equiv), and benzoquinone (0.5 equiv) in NMP, a wide range of olefins were coupled with various 2-nitrobenzoates at 130 °C with the release of carbon dioxide to afford the corresponding vinyl arenes in good yields.
