924650-17-9Relevant academic research and scientific papers
Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE
Wu, Yong-Jin,Zhang, Yunhui,Good, Andrew C.,Burton, Catherine R.,Toyn, Jeremy H.,Albright, Charles F.,Macor, John E.,Thompson, Lorin A.
scheme or table, p. 2654 - 2660 (2010/01/16)
A series of N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)-butan-2-yl)benzamides has been synthesized as BACE inhibitors. A variety of P2 and P3 substituents has been explored, and these efforts have culminated in the identification
β SECRETASE INHIBITOR
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Page/Page column 40-41, (2008/06/13)
Disclosed is a compound represented by the formula (1) below which is useful as a drug for treating Alzheimer's disease, or a pharmaceutically acceptable salt thereof. (1) [In the formula, R1 represents a group represented by the following formula (2): (2) (wherein X represents a nitrogen atom or a group expressed as C(R5); Y represents a nitrogen atom or a group expressed as C(R6); and R5 and R6 independently represent a hydrogen atom or the like) or the like; m represents an integer of 1-6; L1 represents a single bond or the like; R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group or the like; R3 represents a hydrogen atom or the like; L2 represents a single bond or the like; and R4 represents a hydrogen atom, a substituted or unsubstituted aryl group or the like.]
Novel phenylcarboxyamides as beta-secretase inhibitors
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Page/Page column 33, (2008/06/13)
There is provided a series of novel phenylcarboxyamides of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and Y as defined herein, their pharmaceutical compositions and
