924654-97-7

Upstream product

• 611-73-4 Benzoylformic acid 
• 110-83-8 cyclohexene 
• 17199-29-0 (S)-Mandelic acid 
• 924654-89-7 (S)-Hydroxy-phenyl-acetic acid (1R,2R)-2-bromo-cyclohexyl ester 

Downstream Products

• 168749-08-4 (1R,2S)-cis-2-azidocyclohexanol 
• 924655-00-5 (+)-cis-(1R,2S)-2-(phenylthio)-1-cyclohexanol 
• 924654-98-8 Oxo-phenyl-acetic acid (1R,2S)-2-phenylsulfanyl-cyclohexyl ester 
• 924654-99-9 Oxo-phenyl-acetic acid (1R,2S)-2-azido-cyclohexyl ester 

Relevant academic research and scientific papers

First asymmetric intermolecular bromoesterification catalyzed by chiral Bronsted acid

The first successful enantioselective intermolecular bromoesterification was realized by using a chiral phosphoric acid as a catalyst. The reaction was optimized after screening 2-aminopyridine based basic catalysts, cinchona alkaloid based basic catalyst

Single enantiomer epoxides by bromomandelation of prochiral alkenes

A combination of mandelic acid and N-bromosuccinimide efficiently converts prochiral alkenes into a readily separable 1:1 mixture of the bromomandelates. The diastereomerically pure bromomandelates are then converted into a variety of enantiomerically pure products. Terminal alkenes are converted into enantiomerically pure epoxides. Cyclohexene is converted into enantiomerically pure cis-2-azidocyclohexanol and cis-2-phenylthiocyclohexanol.