924663-38-7

Basic information

• Product Name: RABEPRAZOLE N-OXIDE
• Synonyms: RABEPRAZOLE N-OXIDE;2-[[[1-Oxide-4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole;2-[[[4-(3-Methoxypropoxy)-3-methyl-1-oxido-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole;2-[[[4-(3-Methoxypropoxy)-3-Methyl-1-oxido-2-pyridinyl]Methyl]sulfinyl]-;Rabeprazole IMpurity-N-Oxide;Rabeprazole IMpurity A;Rabeprazole Related CoMpound B;2-(((4-(3-Methoxypropoxy)-3-methyl-1-oxopyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole
• CAS NO: 924663-38-7
• Molecular Formula: C₁₈H₂₁N₃O₄S
• Molecular Weight: 375.44
• Product Categories: Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 924663-38-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 161-163°C
• Boiling Point: 699.328°C at 760 mmHg
• Flash Point: 376.74°C
• Appearance: /
• Density: 1.367g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly)
• CAS DataBase Reference: RABEPRAZOLE N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: RABEPRAZOLE N-OXIDE(924663-38-7)
• EPA Substance Registry System: RABEPRAZOLE N-OXIDE(924663-38-7)

Safety Data

• Hazardous Substances Data: 924663-38-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 924663-38-7 differently. You can refer to the following data:
1. Rabeprazole N-Oxide (Rabeprazole EP Impurity D) is a Rabeprazole (R070500) impurity.
2. Rabeprazole impurity

InChI:InChI=1/C18H21N3O4S/c1-13-16(21(22)9-8-17(13)25-11-5-10-24-2)12-26(23)18-19-14-6-3-4-7-15(14)20-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,19,20)

Upstream product

• 924663-40-1 2-[[(4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole 
• 37699-43-7 2,3-dimethyl-4-nitropyridine N-oxide 
• 1589-49-7 methoxypropanol 
• 134469-07-1 Benzimidazol-2-thiol 

Downstream Products

• 117976-89-3 rabeprazole 

Relevant articles and documents

Process for the preparation of pyridine-methylsulfinyl compounds

A process for the preparation of a compound of formula (I), or a salt thereof, wherein Q is ═CR8— or ═N—; and R1-R8 are as herein defined; comprising the reaction of a compound of formula (II), or a salt thereof, wherein Q, R1-R7 are as herein defined; with a reducing agent selected from a trivalent phosphorous compound, an oxidizable solvent and a sulfonic acid chloride; and, if desired, the conversion of a compound of formula (I) to another compound of formula (I) or a salt thereof.

A process for the preparation of pyridine-methylsulfinyl compounds

A process for the preparation of a compound of formula (I), or a salt thereof, wherein Q is =CR8- or =N-; and R1-R8 are as herein defined; comprising the reaction of a compound of formula (II), or a salt thereof, wherein Q, R1-R7 are as herein defined; with a reducing agent selected from a trivalent phosphorous compound, an oxidizable solvent and a sulfonic acid chloride; and, if desired, the conversion of a compound of formula (I) to another compound of formula (I) or a salt thereof.

Synthetic studies connected with the preparation of H+/K +-ATPase inhibitors rabeprazole and lansoprazole

Synthesis of lansoprazole and rabeprazole using common intermediates is devised. The common intermediates, 2-[(4-nitro-3-methylpyridin-2-yl) methanesulfanyl]-1H-benzoimidazole and 2-[(4-chloro-3-methyl-pyridin-2-yl) methanesulfanyl]-1H-benzoimidazole, were prepared in several ways.