924708-48-5

Basic information

• Product Name: Phenol, 2-ethenyl-4-iodo-
• CAS NO: 924708-48-5
• Molecular Formula: C8H7IO
• Molecular Weight: 246.047
• Mol File: 924708-48-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phenol, 2-ethenyl-4-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-ethenyl-4-iodo-(924708-48-5)
• EPA Substance Registry System: Phenol, 2-ethenyl-4-iodo-(924708-48-5)

Safety Data

• Hazardous Substances Data: 924708-48-5(Hazardous Substances Data)

Upstream product

• 1761-62-2 5-iodosalicyclaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 38170-02-4 4-iodosalicylaldehyde 
• 90-02-8 salicylaldehyde 

Downstream Products

• 924708-52-1 toluene-4-sulfonic acid 2-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenoxy]-5-iodo-phenyl}-2-hydroxy-ethyl ester 
• 924708-50-9 (R)-1-(2-(4-(tert-butyldimethylsilyloxy)phenoxy)-5-iodophenyl)ethane-1,2-diol 
• 924708-54-3 (R)-2-(2-(4-(tert-butyldimethylsilyloxy)phenoxy)-5-iodophenyl)propan-1-ol 
• 924708-53-2 (S)-2-(2-(4-(tert-butyldimethylsilyloxy)phenoxy)-5-iodophenyl)propan-1-ol 
• 924708-51-0 (R)-tert-butyl(4-(4-iodo-2-(oxiran-2-yl)phenoxy)phenoxy)dimethylsilane 
• 925230-87-1 4-[2-(2-hydroxy-1-methyl-ethyl)-4-propenyl-phenoxy]-phenol 
• 132114-11-5 ratanhine 
• 943341-57-9 C₄₀H₃₈O₈ 
• 943341-63-7 (2-(1-bromoethenyl)-4-iodophenyl)-4-methoxymethoxybenzoate 
• 943341-62-6 (2-(1,2-dibromoethyl)-4-iodophenyl)-4-methoxymethoxybenzoate 
• 943341-61-5 (2-vinyl-4-iodophenyl)-4-methoxymethoxybenzoate 
• 924708-49-6 tert-butyl(4-(4-iodo-2-vinylphenoxy)phenoxy)dimethylsilane 

Relevant articles and documents

Aryl derivatives of 3H-1,2-benzoxathiepine 2,2-dioxide as carbonic anhydrase inhibitors

A new series of homosulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) possessing various substitution patterns and moieties in the 7, 8 or 9 position of the heterocylic ring were prepared by original procedures and investigated for the inhibition of four physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the human (h) hCA I, II, IX and XII. The 8-substituted homosulfocoumarins were the most effective hCA IX/XII inhibitors followed by the 7-substituted derivatives, whereas the substitution pattern in position 9 led to less effective binders for the transmembrane, tumour-associated isoforms IX/XII. The cytosolic isoforms hCA I and II were not inhibited by these compounds, similar to the sulfocoumarins/coumarins investigated earlier. As hCA IX and XII are validated anti-tumour targets, with one sulphonamide (SLC-0111) in Phase Ib/II clinical trials, finding derivatives with better selectivity for inhibiting the tumour-associated isoforms over the cytosolic ones, as the homosulfocoumarins reported here, is of crucial importance.

Concise synthesis of rodgersinol and determination of the C-10 absolute configuration

Rodgersinol was synthesized via seven linear steps in 31% overall yield, and the absolute configuration of the C-10 stereogenic center was elucidated. The key feature of the synthesis involves the efficient Cu(II)-mediated coupling of two aromatic moietie