924715-43-5Relevant articles and documents
Arylureas derived from colchicine: Enhancement of colchicine oncogene downregulation activity
Blasco, Víctor,Cu?at, Ana C.,Sanz-Cervera, Juan F.,Marco, J. Alberto,Falomir, Eva,Murga, Juan,Carda, Miguel
, p. 817 - 828 (2018)
Our efforts to get therapeutically useful colchicine derivatives for the treatment of cancer have led us to synthetize and biologically evaluate twenty-seven N,N′-disubstituted ureas containing a colchicine moiety and an aryl fragment. The cytotoxicity of
In situ generation and trapping of thioimidates: An intermolecular tandem reaction to 4-acylimino-4H-3,1-benzothiazines
Steinebach, Christian,Schulz-Fincke, Anna-Christina,Schnakenburg, Gregor,Gütschow, Michael
, p. 15430 - 15440 (2016/02/23)
The proton-catalyzed transformation of 2-thioureidobenzonitriles to 4-acylimino-4H-3,1-benzothiazines was accomplished by treatment with carboxylic anhydrides, acid chlorides or alkyl chloroformates. The reaction involves a cyclization to 4-imino-3,1-benz