924717-67-9

Upstream product

• 124-38-9 carbon dioxide 
• 1359987-48-6 4-fluorophenyl(tributylstannyl)methyl acetate 
• 459-57-4 4-fluorobenzaldehyde 
• 3798-61-6 1-(4-fluorophenyl)prop-2-yn-1-ol 
• 948859-48-1 1-(4-fluorophenyl)prop-2-yn-1-yl acetate 

Downstream Products

• 1201196-50-0 2-Chloro-5-{[2-(4-fluoro-phenyl)-2-oxo-acetyl]-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amino}-N-methyl-benzamide 
• 1201195-66-5 (R,S)-2-(4-fluoro-phenyl)-2-hydroxy-N-(1-methyl-1H-indol-6-yl)-N-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-acetamide 
• 1201196-06-6 (R,S)-N-(4-fluoro-3-methyl-phenyl)-2-(4-fluoro-phenyl)-2-hydroxy-N-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-acetamide 
• 1201196-47-5 (R,S)-acetic acid {(4-chloro-3-hydroxymethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-carbamoyl}-(4-fluoro-phenyl)-methyl ester 
• 1359987-65-7 methyl 2-acetoxy-2-(4-fluorophenyl)acetate 
• 347850-66-2 2-chloro-1-(4-fluorophenyl)-2-oxoethyl acetate 
• 948859-49-2 ethyl 4-acetoxy-4-(4-fluorophenyl)-2-methyl-3-oxobutanoate 

Relevant academic research and scientific papers

Α-hydroxyacid salt

PROBLEM TO BE SOLVED: To provide a novel method for manufacturing a salt of α-hydroxy acid as an intermediate for synthesizing α-hydroxy acid derivatives which promotes carboxylation promptly by the COsupplementation reaction even if the substrate having

Synthesis of arylglycine and mandelic acid derivatives through carboxylations of α-amido and α-acetoxy stannanes with carbon dioxide

Incorporation reactions of carbon dioxide (CO2) with N-Boc-α-amido and α-acetoxy stannanes were developed using CsF as a mild tin activator. Monoprotected α-amido stannanes could be used, and the corresponding arylglycine derivatives were obtained in moderate-to-high yields under 1 MPa (10 atm) of CO2 pressure. α-Acetoxy stannanes also underwent carboxylation to afford mandelic acid derivatives in excellent yields under ambient CO2 pressure. Both transformations enabled the synthesis of α-tertiary and α-quaternary carboxylic acid derivatives. In addition, the chirality of (S)-N-tert-butylsulfonyl-α- amido stannanes was transferred with up to 90% inversion of configuration at 100 °C.

A versatile route to C-6 arylmethyl-functionalized S-DABO and related analogues

Since their discovery in 1992,3,4-dihydro-2-alkoxy-6-benzyl-4- oxypyrimidines (DABOs) have been subjected to many structural modifications in order to obtain better non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of AIDS. Herein