92472-64-5

Basic information

• Product Name: N,N-diethyl-3-(methylimino)-4-methyl-4-aza-5α-androstane-17β-carboxamide
• CAS NO: 92472-64-5
• Molecular Weight: 401.636
• Mol File: 92472-64-5.mol

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-3-(methylimino)-4-methyl-4-aza-5α-androstane-17β-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-3-(methylimino)-4-methyl-4-aza-5α-androstane-17β-carboxamide(92472-64-5)
• EPA Substance Registry System: N,N-diethyl-3-(methylimino)-4-methyl-4-aza-5α-androstane-17β-carboxamide(92472-64-5)

Safety Data

• Hazardous Substances Data: 92472-64-5(Hazardous Substances Data)

Upstream product

• 92472-63-4 17β-(diethylamino carbonyl)-3-methoxy-4-methyl-4-azonia-5α-androst-3-ene-methylsulfate 
• 74-89-5 methylamine 

Relevant articles and documents

Azasteroids as Inhibitors of Rat Prostatic 5α-Reductase

A series of A-ring heterocyclic steroids has been prepared and tested for inhibition of rat prostatic steroid 5α-reductase in vitro.Strinkingly high inhibitory activity was found with a group of 17β-substituted 4-methyl-4-aza-5α-androstan-3-ones.These compounds were prepared from 3-keto-Δ4-precursors by oxidative (O3 or NaIO4-KMnO4) A-ring cleavage followed, in turn, by ring closure with an amine and hydrogenation over platinum catalyst.Other A-ring azasteroids were made by Beckmann rearrangement of oximes of 2-oxo-A-nor-, 3-oxo- and 4-oxo-5α-androstanes.An A-nor-2-oxo-3-azasteroid was prepared by oxidative decarbonylation of a precursor 2,3-dioxo-4-azasteroid with m-chloroperbenzoic acid.A-ring modifications of the 4-azasteroids included Δ1-unsaturation, 2- and 4-substituents, and 3-carbonyl replacements.Side chains at the 17-position were varied with an emphasis on carboxylate derivatives (salts, esters, and amides).