924854-62-6 Usage
Description
2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3S,11bS)is a complex organic compound with a unique molecular structure. It belongs to the class of benzoquinolizinols and is characterized by its hexahydro, dimethoxy, and methylpropyl functional groups. The stereochemistry of the compound is defined by the (2R,3S,11bS) configuration, which plays a crucial role in its properties and potential applications.
Uses
Used in Pharmaceutical Industry:
2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3S,11bS)is used as an inhibitor of vascular monoamine transporter 2 (VMAT2) for its potential therapeutic applications in the treatment of various neurological disorders. VMAT2 is responsible for the transport of monoamines, such as dopamine, serotonin, and norepinephrine, into synaptic vesicles. Inhibition of VMAT2 can lead to reduced levels of these neurotransmitters in the synaptic cleft, which may help alleviate symptoms associated with certain conditions.
2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3S,11bS)-'s unique structure and stereochemistry may also contribute to its selectivity and potency as a VMAT2 inhibitor, making it a promising candidate for further research and development in the pharmaceutical industry. However, it is essential to conduct extensive studies to evaluate its safety, efficacy, and potential side effects before it can be considered for clinical use.
Check Digit Verification of cas no
The CAS Registry Mumber 924854-62-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,4,8,5 and 4 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 924854-62:
(8*9)+(7*2)+(6*4)+(5*8)+(4*5)+(3*4)+(2*6)+(1*2)=196
196 % 10 = 6
So 924854-62-6 is a valid CAS Registry Number.
924854-62-6Relevant articles and documents
Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors
Yao, Zhangyu,Wei, Xueying,Wu, Xiaoming,Katz, Jonathan L.,Kopajtic, Theresa,Greig, Nigel H.,Sun, Hongbin
, p. 1841 - 1848 (2011/05/07)
Tetrabenazine (TBZ) ((±)-1) and dihydrotetrabenazines (DHTBZ) are potent inhibitors of VMAT2. Herein, a practical chemical resolution of (±)-1 and stereoselective synthesis of all eight DHTBZ stereoisomers are described. The result of VMAT2 binding assay revealed that (+)-1 (Ki = 4.47 nM) was 8000-fold more potent than (-)-1 (Ki = 36,400 nM). Among all eight DHTBZ stereoisomers, (2R,3R,11bR)-DHTBZ ((+)-2: Ki = 3.96 nM) showed the greatest affinity for VMAT2. The (3R,11bR)-configuration appeared to play a key role for VMAT2 binding. In summary, (+)-1, (+)-2, and their derivatives warrant further studies in order to develop more potent and safer drugs for the treatment of chorea associated with Huntington's disease and other hyperkinetic disorders.
3, HB CIS DIHYDROTETRABANEZINE FOR THE TREATMENT OF SCHIZOPHRENIA AND OTHER PSYCHOSES
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Page/Page column 26-27, (2008/06/13)
The invention provides the use of 3,1l b-cis-dihydrotetrabenazine or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prophylaxis or treatment of schizophrenia and other psychoses.
