924869-27-2

Basic information

• Product Name: TERT-BUTYL 2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLATE
• Synonyms: TERT-BUTYL 2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLATE;2,4,6,7-Tetrahydro-5H-pyrazolo[4,3-c]pyridine, N5-BOC protected;tert-Butyl 6,7-dihydro-2H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate;tert-butyl 2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5- carboxylate;tert-Butyl 2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate, 5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine;5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 2,4,6,7-tetrahydro-, 1,1-dimethylethyl ester
• CAS NO: 924869-27-2
• Molecular Formula: C₁₁H₁₇N₃O₂
• Molecular Weight: 223.27158
• Mol File: 924869-27-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 127-128°C
• Boiling Point: 388.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.200±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.99±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLATE(924869-27-2)
• EPA Substance Registry System: TERT-BUTYL 2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLATE(924869-27-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 924869-27-2(Hazardous Substances Data)

Usage

General Description

Tert-butyl 2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate is a chemical compound with the molecular formula C14H18N2O2. It is a pyrazole derivative that is often used in pharmaceutical research and development, particularly in the synthesis of potential drug candidates. TERT-BUTYL 2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLATE is known for its diverse biological activities, including its potential anticonvulsant and analgesic properties. Its tert-butyl group and carboxylate functional group contribute to its stability and chemical reactivity, making it a valuable building block in the development of novel pharmaceuticals.

Upstream product

• 1202645-17-7 3-dimethylaminomethylene-4-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 157327-41-8 t-butyl-3-[(dimethylamino)methylidene]-4-oxopiperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1310796-19-0 (Z)-3-((dimethylamino)methylene)-4-oxopiperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 933742-87-1 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 
• 1449369-14-5 (5-methyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-2-yl)-acetic acid benzyl ester 
• 1449369-15-6 (5-methyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl)-acetic acid benzyl ester 
• 1449369-18-9 (1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl)acetic acid benzyl ester 
• 100501-57-3 tert-butyl 2-methyl-6,7-dihydro-2H-pyrazolo(4,3-c)pyridine-5(4H)-carboxylate 
• 100501-58-4 1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 
• 661487-17-8 tert-butyl 3-iodo-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate 
• 1373223-68-7 4,5,6,7-tetrahydro-2-(3-pyridinyl)-2H-pyrazolo[4,3-c]pyridine 
• 1258976-24-7 1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo-[4,3-c]pyridine-5-carboxylate 

Relevant articles and documents

Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold

A series of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold were identified with good cellular and human whole blood activity against IDO1. These inhibitors contain multiple chiral centers and all diastereomers were separated. The absolute stereochemistry of each isomers were not determined. Compounds 15 and 27 stood out as leads due to their good cellular as well as human whole blood IDO1 inhibition activity, low unbound clearance, and reasonable mean residence time in rat cassette PK studies.

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

BICYCLIC PYRAZOLE PESTICIDES

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, (1) wherein Q is (Q-1) or (Q-2); and A, R1, m, X1, X1a, X1b, X2, R2, R5, q and t are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.