924884-89-9

Upstream product

• 924884-87-7 (1S,6S)-(+)-2,2-dimethyl-1-[3'-(benzothiazole-2''-sulfanyl)butyl]-6-methoxymethyloxycyclohexane 
• 924884-78-6 (1S,6S)-2,2-dimethyl-1-(2'-methoxycarbonyl-3'-oxobutyl)-6-methoxymethyloxycyclohexane 
• 924884-79-7 (1S,6S)-(+)-2,2-dimethyl-1-(3'-oxobutyl)-6-methoxymethyloxycyclohexane 
• 924884-80-0 (1S,6S)-2,2-dimethyl-1-(3'-hydroxybutyl)-6-methoxymethyloxycyclohexane 
• 924884-75-3 (1S,6S)-(-)-2,2-dimethyl-1-methoxycarbonyl-6-methoxymethyloxycyclohexane 
• 924884-77-5 (1S,6S)-(+)-2,2-dimethyl-1-iodomethyl-6-methoxymethyloxycyclohexane 
• 924884-76-4 (1R,6S)-(+)-2,2-dimethyl-1-hydroxymethyl-6-methoxymethyloxycyclohexane 

Downstream Products

• 924884-90-2 (S)-2,2-dimethyl-1-[3'-(benzothiazole-2''-sulfanyl)butyl]-6-methylenecyclohexane 

Relevant academic research and scientific papers

New total synthesis of (+)-ambrein

The convergent synthesis of (+)-ambrein 1 was achieved based on a modified Julia coupling reaction between aldehyde 14 corresponding to the left-half A and sulfone 25a or 25b corresponding to the right-half B. Aldehyde 14 was synthesized in 14% overall yield (nine steps) from the enzymatic resolution product, epoxy alcohol (8aS)-2. Sulfone 25a or 25b was synthesized in 11 steps (25a: 41% overall yield, 25b: 56% overall yield) from the enzymatic resolution product, (1S,6S)-2,2-dimethyl-6-hydroxyhexane-1-carboxylate 4.