924884-90-2

Upstream product

• 149-30-4 2-Mercaptobenzothiazole 
• 502763-34-0 (S)-1-[1′-benzenesulfonyl]methyl-2,2-dimehtyl-6-methylenecyclohexane 
• 502763-33-9 (S)-(-)-2,2-dimethyl-6-methylene-1-[1'-(phenylthio)methyl]cyclohexane 
• 188540-03-6 Methanesulfonic acid (S)-2,2-dimethyl-6-methylene-cyclohexylmethyl ester 
• 166022-29-3 (S)-(+)-(2',2'-dimethyl-6'-methylene-1'-cyclohexyl)methanol 
• 472-19-5 (2,2-dimethyl-6-methylenecyclohexyl)methanol 
• 924884-89-9 (1S,6S)-2,2-dimethyl-1-[3'-(benzothiazole-2''-sulfanyl)butyl]-6-oxocyclohexane 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 502763-37-3 (2E,6E)-9-((1S)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene 

Relevant academic research and scientific papers

Preparation of (S)-γ-cyclogeraniol by lipase-catalyzed transesterification and synthesis of (+)-trixagol and (+)-luffarin-P

Lipase-catalyzed kinetic resolution of γ-cyclogeraniol by Candida antarctica lipase B yielded 23% of enantiomerically pure (S)-γ-cyclogeraniol. (+)-trixagol and (+)-luffarin-P were synthesized from the obtained (S)-γ-cyclogeraniol, and the absolute config

New total synthesis of (+)-ambrein

The convergent synthesis of (+)-ambrein 1 was achieved based on a modified Julia coupling reaction between aldehyde 14 corresponding to the left-half A and sulfone 25a or 25b corresponding to the right-half B. Aldehyde 14 was synthesized in 14% overall yield (nine steps) from the enzymatic resolution product, epoxy alcohol (8aS)-2. Sulfone 25a or 25b was synthesized in 11 steps (25a: 41% overall yield, 25b: 56% overall yield) from the enzymatic resolution product, (1S,6S)-2,2-dimethyl-6-hydroxyhexane-1-carboxylate 4.