924907-34-6

Basic information

• Product Name: Pyrrolidine, 2-[(2-chlorophenoxy)methyl]-, (2R)-
• CAS NO: 924907-34-6
• Molecular Formula: C11H14ClNO
• Molecular Weight: 211.691
• Mol File: 924907-34-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 2-[(2-chlorophenoxy)methyl]-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 2-[(2-chlorophenoxy)methyl]-, (2R)-(924907-34-6)
• EPA Substance Registry System: Pyrrolidine, 2-[(2-chlorophenoxy)methyl]-, (2R)-(924907-34-6)

Safety Data

• Hazardous Substances Data: 924907-34-6(Hazardous Substances Data)

Upstream product

• 59378-81-3 1-(tert-butoxycarbonyl)prolin-2R-ol 
• 73323-65-6 1-(tert-butyl) 2-methyl (R)-pyrrolidine-1,2-dicarboxylate 
• 43041-12-9 methyl (2R)-pyrrolidine-2-carboxylate 
• 344-25-2 D-Prolin 

Downstream Products

• 924907-14-2 6-[(R)-2-(2-chlorophenoxymethyl)-pyrrolidin-1-yl]-9H-purine 
• 1201581-67-0 7-[(R)-2-(2-chlorophenoxymethyl)pyrrolidin-1-yl]-3H-imidazo[4,5-b]pyridine 
• 1201581-68-1 4-[(R)-2-(2-chlorophenoxymethyl)pyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine 
• 1201580-81-5 7-[(R)-2-(2-chlorophenoxymethyl)pyrrolidin-1-yl]-1,2,5-thiadiazolo[3,4-b]pyridine 
• 1201580-99-5 4-[(R)-2-(2-chlorophenoxymethyl)pyrrolidin-1-yl]-pyrido[2,3-d]pyrimidine 

Relevant articles and documents

Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates

The natural product fumagillin 1 and derivatives like TNP-470 2 or beloranib 3 bind to methionine aminopeptidase 2 (MetAP-2) irreversibly. This enzyme is critical for protein maturation and plays a key role in angiogenesis. In this paper we describe the synthesis, MetAP-2 binding affinity and structural analysis of reversible MetAP-2 inhibitors. Optimization of enzymatic activity of screening hit 10 (IC50: 1?μM) led to the most potent compound 27 (IC50: 0.038?μM), with a concomitant improvement in LLE from 2.1 to 4.2. Structural analysis of these MetAP-2 inhibitors revealed an unprecedented conformation of the His339 side-chain imidazole ring being co-planar sandwiched between the imidazole of His331 and the aryl-ether moiety, which is bound to the purine scaffold. Systematic alteration and reduction of H-bonding capability of this metal binding moiety induced an unexpected 180° flip for the triazolo[1,5-a]pyrimdine bicyclic template.