92491-23-1

Upstream product

• 14599-72-5 4,5-dihydro-1-(3-methoxyphenyl)imidazol-2(1H)-one 
• 74-88-4 methyl iodide 
• 536-90-3 m-Anisidine 
• 14088-85-8 N¹-(3-methoxyphenyl)ethane-1,2-diamine 

Relevant academic research and scientific papers

Lithiation of 1-arylimidazol-2(1H)-ones and 1-aryl-4,5-dihydroimidazol- 2(1H)-ones

1-Arylimidazol-2(1H)-ones are shown to be readily lithiated, using 2 mol equiv. of n-butyllithium, on the benzene ring, ortho to the heterocycle. 1-Aryl-4,5-dihydroimidazol-2(1H)-ones also undergo metalation on the aromatic substitutuent ortho to the heterocycle, but less efficiently. 1-Aryl-3-methylimidazol-2(1H)-ones are lithiated on the heterocyclic ring and then on the benzene ring ortho to the heterocycle. No ortho-directing effect was found for 1-aryl-4,5-dihydro-3-methylimidazol-2(1H)-ones.