92496-93-0

Upstream product

• 95280-53-8 5,8-dimethoxy-2-phenyl-chroman-4-one 
• 10035-10-6 hydrogen bromide 
• 108-24-7 acetic anhydride 

Downstream Products

• 93012-38-5 5-hydroxy-8-methoxy-2-phenyl-chroman-4-one 
• 95280-52-7 5,6-dimethoxyflavanone 

Relevant academic research and scientific papers

Preparation method of 5,7-dihydroxy flavanone

The invention provides a preparation method of 5,7-dihydroxy flavanone. The preparation method comprises the following steps: performing ring-opening reaction on naringin in an alkaline solution, and obtaining velamen acetyl benzene-4'-neohesperidin; performing ring-closing condensation reaction on the velamen acetyl benzene-4'-neohesperidin, benzaldehyde and a catalyst in an alcohol solvent under the protection of inert gas to obtain a naringin analogue, wherein the catalyst is a mixture of acetic acid and pyrrolidine; performing deglycosylation on the naringin analogue and the deglycosylation enzyme in a buffer solution, and obtaining the 5,7-dihydroxy flavanone. The 5,7-dihydroxy flavanone can be obtained by three-step reaction, the procedures are simple, the reaction condition is moderate, the yield is high, and the environmental pollution is small; the preparation method provided by the invention adopts naringin as a starting raw material, so that the source of the raw material is wide, the cost is low, and the preparation method is suitable for the industrialized production.