924964-23-8

Usage

Common use

Building block in the synthesis of various pharmaceutical drugs

Industry

Pharmaceutical industry

Derivative of

Piperazine

Known for

High reactivity

Used as

Reagent in organic synthesis

Potential applications

Development of new drugs and drug delivery systems

Safety

Handle with care, can be hazardous if not properly handled and stored

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 76535-75-6 di-tert-butyl piperazine-1,4-dicarboxylate 
• 927883-45-2 2-carbamoylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester 

Relevant academic research and scientific papers

C(sp3)?H Cyanation Promoted by Visible-Light Photoredox/Phosphate Hybrid Catalysis

Inspired by the reaction mechanism of photo-induced DNA cleavage in nature, a C(sp3)?H cyanation reaction promoted by visible-light photoredox/phosphate hybrid catalysis was developed. Phosphate radicals, generated by one-electron photooxidation of phosphate salt, functioned as a hydrogen-atom-transfer catalyst to produce nucleophilic carbon radicals from C(sp3)?H bonds with a high bond-dissociation energy. The resulting carbon radicals were trapped by a cyano radical source (TsCN) to produce the C?H cyanation products. Due to the high functional-group tolerance and versatility of the cyano group, the reaction will be useful for realizing streamlined building block syntheses and late-stage functionalization of drug-like molecules.

Cinnamamide compounds as metabotropic glutamate receptor antagonists

The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where R1, R2, R3, A, X, and n are defined in the description. The invention also includes pharmaceutical composition