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92498-03-8

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92498-03-8 Usage

Class

Isoindoles

Common uses

Synthesis of pharmaceuticals and agrochemicals

Physical form

White solid

Molecular weight

303.3 g/mol

Usage

Building block in organic synthesis

Role

Precursor for production of various drugs and biologically active molecules

Safety

Handle with caution and follow safety guidelines due to potentially hazardous nature.

Check Digit Verification of cas no

The CAS Registry Mumber 92498-03-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,4,9 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 92498-03:
(7*9)+(6*2)+(5*4)+(4*9)+(3*8)+(2*0)+(1*3)=158
158 % 10 = 8
So 92498-03-8 is a valid CAS Registry Number.

92498-03-8Relevant articles and documents

Tunable System for Electrochemical Reduction of Ketones and Phthalimides

Chen, Gong,Qiao, Tianjiao,Wang, Yaxin,Zhang, Jian,Zhao, Jianyou

supporting information, p. 3297 - 3302 (2021/10/14)

Herein, we report an efficient, tunable system for electrochemical reduction of ketones and phthalimides at room temperature without the need for stoichiometric external reductants. By utilizing NaN3 as the electrolyte and graphite felt as both the cathode and the anode, we were able to selectively reduce the carbonyl groups of the substrates to alcohols, pinacols, or methylene groups by judiciously choosing the solvent and an acidic additive. The reaction conditions were compatible with a diverse array of functional groups, and phthalimides could undergo one-pot reductive cyclization to afford products with indolizidine scaffolds. Mechanistic studies showed that the reactions involved electron, proton, and hydrogen atom transfers. Importantly, an N3/HN3 cycle operated as a hydrogen atom shuttle, which was critical for reduction of the carbonyl groups to methylene groups.

Syntheses of the substituted derivatives of 2-phenoxymethyl-1H-isoindol-1,3(2H)-dione in homogeneous and heterogeneous media, under the action of electromagnetic microwaves

Bratulescu, George

, p. 261 - 264 (2007/10/03)

Some ethers derived from the 2-(phenoxymethyl)-1H-isoindol-1,3(2H)-dione were synthetized in isopropanol medium. The same compounds were also prepared in a dry medium, without solvent and absorbent inorganic support by using electromagnetic microwaves.

Mechanism of Hydrolysis of O-Imidomethyl Derivatives of Phenols

Getz, John J.,Prankerd, Richard J.,Sloan, Kenneth B.

, p. 4913 - 4918 (2007/10/02)

Three series of O-imidomethyl derivatives of para-substituted phenolic compounds were synthesized and their rates of hydrolysis were studied.Saccharin, phthalimide, and succinimide served as the imide portions of the derivatives.Their rates of hydrolysis were found to be first order with respect to hydroxide from pH 7.0 to 10 or 11 and dependent on the acidity (leaving group potential) of both the imide and the phenol portions.The more acidic the imide or the phenol, the faster the rate of hydrolysis.However, the rates of hydrolysis were more sensitive to the acidity of the phenol.Trapping experiments with cyanide also suggested that the phenol anion was functioning as the leaving group in what is apparently an SN2 reaction.An amide derivative was found to hydrolyze more slowly than predicted from the analogous series and the pKa of the amide.This result is apparently due partially stereoelectronic constraints in the imide series that cause the CH2-O bond to be oriented more nearly perpendicular to the plane of the C(=O)N group and hence more accessible to nucleophilic attack.

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