925006-44-6

Usage

Uses

Used in Pharmaceutical Development:
1-(6-(4-BROMOPHENYL)-2-METHYLPYRIDIN-3-YL)ETHANONE is used as a building block for the development of pharmaceuticals due to its unique chemical structure and potential to be incorporated into various drug molecules.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(6-(4-BROMOPHENYL)-2-METHYLPYRIDIN-3-YL)ETHANONE serves as an important intermediate, contributing to the creation of a wide range of chemical compounds with diverse applications.
Used in Medicinal Chemistry:
1-(6-(4-BROMOPHENYL)-2-METHYLPYRIDIN-3-YL)ETHANONE is utilized in medicinal chemistry as a key component in the design and synthesis of biologically active molecules, potentially leading to the discovery of new therapeutic agents.

Upstream product

• 73387-60-7 (2E)-1-(4-bromophenyl)-3-(dimethylamino)prop-2-en-1-one 
• 123-54-6 acetylacetone 
• 99-90-1 para-bromoacetophenone 
• 73387-60-7 1-(4-bromophenyl)-3-(dimethylamino)prop-2-en-1-one 
• 50-00-0 formaldehyd 
• 299456-72-7 1-(4-bromophenyl)ethanone O-acetyl oxime 

Relevant academic research and scientific papers

Novel 2-methyl-6-arylpyridines carrying active pharmacophore 4,5-dihydro 2-pyrazolines: synthesis, antidepressant, and anti-tuberculosis evaluation

As part of the effort to develop new hybrid molecules for the treatment of depression and tuberculosis, a new series of novel 6-aryl-2-methyl-3-(5-aryl-4,5-dihydro-1H-pyrazol-3yl)pyridines 5a–l were synthesized. These compounds were screened for in vivo a

Cu-Catalyzed Three-Component Cascade Annulation Reaction: An Entry to Functionalized Pyridines

A concise copper-catalyzed N-O bond cleavage/C-C/C-N bond formation procedure has been described for the synthesis of multisubstituted pyridines. Various oxime acetates, activated methylene compounds, and a wide range of aldehydes bearing aryl, heteroaryl, vinyl, and trifluoromethyl groups were employed to provide the tri- or tetrasubstituted pyridines with flexible substitution patterns. Moreover, this method features inexpensive catalysts, no need for extra oxidant, and high step-enconomy, which make it pratical and attractive.

Microwave-assisted regioselective one-pot synthesis of trisubstituted pyridine scaffolds using K5CoW12O40.3H 2O under solvent free conditions

(Chemical Equation Presented) A highly efficient, microwave-assisted, regioselective synthesis of 2,3-disubstituted-6-arylpyridines and new series of 7,7-dimethyl-2-aryl-5,6,7,8-tetrahydroquinoline-5-ones from enaminones in the presence of K5CoW12O40.3H2O (1.0 mol %) as heterogeneous catalyst under solvent free conditions is reported.

A highly efficient regioselective one-pot synthesis of 2,3,6-trisubstituted pyridines and 2,7,7-trisubstituted tetrahydroquinolin-5-ones using K5CoW12O40·3H2O as a heterogeneous recyclable catalyst

A systematic investigation into the regioselective one-pot, three-component condensation of enaminones 1a-g, β-dicarbonyl compounds 2a-c, and ammonium acetate in the presence of a catalytic amount of K5CoW12O40·3H2O (0.01 equiv or 1.0 mol %) under solvent free conditions, as well as in refluxing isopropanol, has been reported. The reaction was highly efficient to produce 2,3,6-trisubstituted pyridines 3a-g, 4a-g, and novel 2,7,7-trisubstituted-5,6,7,8-tetrahydroquinoline-5-ones 5a-g in excellent yields. The present procedure offers advantages of short reaction time, simple work-up, and the catalyst exhibited remarkable reusable activity.