92510-79-7Relevant academic research and scientific papers
New water soluble Pd-imidate complexes as highly efficient catalysts for the synthesis of C5-arylated pyrimidine nucleosides
Kapdi, Anant,Gayakhe, Vijay,Sanghvi, Yogesh S.,Garcia, Joaquin,Lozano, Pedro,Da Silva, Ivan,Perez, Jose,Serrano, J. Luis
, p. 17567 - 17572 (2014/05/06)
The direct reactions between the precursors trans-[Pd(imidate) 2(SMe2)2] and 1,3,5-triaza-7-phosphaadamantane (PTA) yield new water-soluble palladium(ii) complexes trans-[Pd(imidate) 2(PTA)2](imidate
Synthesis and evaluation of 5-substituted 2′-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in mycobacterium tuberculosis
K?gler, Martin,Vanderhoydonck, Bart,De Jonghe, Steven,Rozenski, Jef,Van Belle, Kristien,Herman, Jean,Louat, Thierry,Parchina, Anastasia,Sibley, Carol,Lescrinier, Eveline,Herdewijn, Piet
experimental part, p. 4847 - 4862 (2011/09/19)
A series of 5-substituted 2′-deoxyuridine monophosphate analogues has been synthesized and evaluated as potential inhibitors of mycobacterial ThyX, a novel flavin-dependent thymidylate synthase in Mycobacterium tuberculosis. A systematic SAR study led to the identification of compound 5a, displaying an IC50 value against mycobacterial ThyX of 0.91 μM. This derivative lacks activity against the classical mycobacterial thymidylate synthase ThyA (IC50 > 50 μM) and represents the first example of a selective mycobacterial FDTS inhibitor.
PALLADIUM(0) CATALYZED COUPLING REACTIONS IN THE SYNTHESIS OF 5-ARYLPYRIMIDINE NUCLEOSIDES
Chang, George,Mertes, Mathias P.
, p. 2431 - 2434 (2007/10/02)
The palladium(0) catalyzed coupling reaction of arylioides and 3',5'-di-O-acetyl-5-chloromercuri-2'-deoxyuridine (1) gave 5-aryl substituted 2'-deoxyuridines.Optimum yields were obtained in diglyme at 120 deg C for 3 hours.
