92513-17-2Relevant articles and documents
A new n-substituted 1h-isoindole-1,3(2h)-dione derivative— synthesis, structure and affinity for cyclooxygenase based on in vitro studies and molecular docking
Szkatu?a, Dominika,Krzy?ak, Edward,Stanowska, Paulina,Duda, Magdalena,Wiatrak, Benita
, (2021/07/19)
Isoindoline-1,3-dione derivatives constitute an important group of medicinal substances. In this study, nine new 1H-isoindole-1,3(2H)-dione derivatives and five potential pharmacophores were obtained in good yield (47.24–92.91%). The structure of the new
Design, synthesis, in vitro and in vivo evaluation of novel pyrrolizine-based compounds with potential activity as cholinesterase inhibitors and anti-Alzheimer's agents
El-Sayed, Nehad Abou-Elmagd,Farag, Awatef El-Said,Ezzat, Manal Abdel Fattah,Akincioglu, Hulya,Gül?in, ?lhami,Abou-Seri, Sahar Mahmoud
, (2019/10/05)
Novel series of pyrrolizine based compounds (4–6 and 9–11) were designed, synthesized and evaluated as potential anti-Alzheimer agents. Most of the tested compounds showed selectivity to hAChE over hBChE and effectively inhibited self–induced amyloid beta
Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
Steinhagen, Henning,Gerisch, Michael,Mittendorf, Joachim,Schlemmer, Karl-Heinz,Albrecht, Barbara
, p. 3187 - 3190 (2007/10/03)
A new class of PARP-1 inhibitors, namely substituted fused uracil derivatives were synthesised. Starting from a derivative with an IC50=2 μM the chemical optimisation program led to compounds with more than a 100-fold increase in potency (ICsu
