92514-07-3Relevant academic research and scientific papers
A two-aromatic substituted propylene ketone compound and its preparation method and application (by machine translation)
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Paragraph 0099; 0100; 0101; 0102; 0103; 0104; 0105, (2019/05/28)
The present invention discloses a two-aromatic substituted propylene ketone compound and its preparation method and application, its structural formula such as formula (I) as shown: Wherein A is B is hydrogen, methyl or ethyl; C is a substituted benzene ring, pyridine and furan heterocyclic, 2 - pyridyl, 3 - pyridyl, 4 - pyridyl, 5 - 1 H - indolyl, 4 - (N, N - dimethylamino) phenyl, 4 - (N - pyrrolyl) phenyl, 4 - [1 - (N - methyl piperazinyl)] phenyl or 4 - (1 - morpholinyl) phenyl. The compounds of the invention has a novel structure, to inhibit the cells MCL active effect, high safety, the preparation cost is low and the like, can be used as a MCL very promising drug. (by machine translation)
Selective inhibitors of Candida albicans dihydrofolate reductase: Activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines
Chan,Hong,Kuyper,Baccanari,Joyner,Tansik,Boytos,Rudolph
, p. 3608 - 3616 (2007/10/03)
The recent increase in fungal infections, especially among AIDS patients, has resulted in the need for more effective antifungal agents. In our search for such agents, we focused on developing compounds which inhibit fungal dihydrofolate reductase (DHFR).
