92516-60-4Relevant academic research and scientific papers
Synthesis and in vitro investigation of potential antiproliferative monosaccharide–D-secoestrone bioconjugates
Bodnár, Brigitta,Mernyák, Erzsébet,Szabó, Johanna,W?lfling, János,Schneider, Gyula,Zupkó, István,Kupihár, Zoltán,Kovács, Lajos
, p. 1938 - 1942 (2017/04/07)
The syntheses of monosaccharide–D-secoestrone conjugates are reported. They were prepared from 3-(prop-2-inyloxy)-D-secoestrone alcohol or oxime and monosaccharide azides via Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC). The antiproliferat
Synthesis of modified D-mannose core derivatives and their impact on GH38 α-mannosidases
Poláková, Monika,Horák, Radim,?esták, Sergej,Holková, Ivana
, p. 62 - 71 (2016/06/01)
Nine new compounds having five- and modified six-member carbohydrate core derived from D-lyxose or D-mannose, and non-hydrolysable aglycones (benzylsulfonyl or aryl(alkyl)triazolyl) were synthesised to investigate their ability to inhibit the recombinant
Anti-(retro)viral conjugates of saccharides and acetamidino or guanidino compounds
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Page/Page column 11-12; 35, (2010/01/31)
Conjugates of a saccharide and an acetamidino- or guanidino-compound, of the formula: wherein A is CH3or NH2; X is a linear or branched C1-C8alkyl chain optionally containing hydroxy, amino and/or oxo groups; n is an integer from 1 to 6, and Sac is the residue of a mono-or oligo-saccharide, provided that when A is NH2and X is -(CH2)3—CH(NH2)—C(=O)-, the monosaccharide residue is not substituted at the position 1, and n is an integer from 2 to 6 when Sac is the residue of an oligosaccharide, are useful as antiviral, particularly as antiretroviral, agents, and can be used either alone or together with other compounds used in AIDS treatment such as AZT and/or protease inhibitors, for the treatment of HIV-infection, AIDS and manifestations of AIDS such as Kaposi sarcoma. Particularly preferred compounds are aminoglycoside-arginine conjugates in which the saccharide is a natural aminoglycoside antibiotic such as kanamycin, gentamycin and neomycin that is conjugated to arginine residues.
