925208-39-5Relevant academic research and scientific papers
BF3·Et2O-catalyzed direct carbon-carbon bond formation of α-EWG ketene-(S,S)-acetals and alcohols and synthesis of unsymmetrical biaryls
Zhang, Qian,Sun, Shaoguang,Hu, Jianglei,Liu, Qun,Tan, Jing
, p. 139 - 143 (2007/10/03)
A highly efficient BF3·OEt2-catalyzed formal dehydration C-C coupling reaction between readily available α-EWG ketene-(S,S)-acetals and various alcohols via direct substitution of the hydroxy group in alcohols has been developed. On the basis of this C-C coupling reaction, a series of alkylated α-EWG ketene-(S,S)-acetals and functionalized 1,4-pentanedienes were prepared in high to excellent yields and the unsymmetrical biaryls were synthesized in good yields from the generated 1,4-pentanedienes and nitroalkanes through a one-pot annulation-aromatization process.
